None listed
Conditions
Brief summary
Everyone knows someone who is scared to go to the doctor or dentist because they are scared of needles. “Needle phobia” is very common and can lead to people avoiding important healthcare and treatments. Therefore, a needle free injection of sedative pain relief could relieve this anxiety in vulnerable population groups. Improving ability of some groups such as children and those with intellectual disabilities and dementia to access healthcare. Making healthcare more pleasant for everyone of all age groups. The study will aim to show that giving a sedative medication to healthy adult volunteers is not painful, is safe and is effective in achieving sedation effects similar to when the medication is given in other ways- for example through the nose.
Interventions
Dexmeditomidine. Single dose.
The medication will be given through the skin and into the muscle in the arm using a jet propulsion device. The device is placed on the arm and once triggered takes less than 1 second to administer the medication into the muscle in the arm.
Initially a dose of 50mcg of Jet injected Dexmedetomidine will be administered to the first 5 volunteers. Once the plasma levels from 50mcg dose are known a decision will be made to continue with 50mcg or increased dose to 100m
Dexmeditomidine. Single dose. The medication will be given through the skin and into the muscle in the arm using a jet propulsion device. The device is placed on the arm and once triggered takes less than 1 second to administer the medication into the muscle in the arm. Initially a dose of 50mcg of Jet injected Dexmedetomidine will be administered to the first 5 volunteers. Once the plasma levels from 50mcg dose are known a decision will be made to continue with 50mcg or increased dose to 100mcg in the second half of the volunteers.
Sponsors
Anaesthetic Research Department
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Adult heathy volunteers
Exclusion criteria
Baseline heart rate of 45 or less Conduction issues on baseline ECG.
Outcome results
None listed