None listed
Conditions
Brief summary
This study will help us learn about how diet, specifically processed-modified protein intake, influences factors related to the health of our gut bacteria and the risk of mood disorders such as depression and anxiety. When we consume high amounts process-modified proteins, these processed proteins may not be digested and used via the normal pathways, but fermented by the gut bacteria, producing various other biologically active compounds. The altered digestion and metabolism of these proteins may be linked with mood disorders, such as depression and anxiety, as a result of altered serotonin production. The researchers will assess how protein is being used in the body through assessing metabolites in blood and urine samples, and assess risk of depression and anxiety using questionnaires, to find out how these are influenced by dietary intake of processed-modified proteins.
Interventions
Participant dietary intake of process-modified protein is the exposure of interest. This will be assessed using a 4-day food diary to assess participants' usual food intake. Participants will complete the food diary at eating occasions over the course of four days prior to attending their study visit. It is estimated that participants will spend approximately 2 hours completing the food diary over the course of 4 days. Levels of process-modified protein consumed will be calculated using food
Participant dietary intake of process-modified protein is the exposure of interest. This will be assessed using a 4-day food diary to assess participants' usual food intake. Participants will complete the food diary at eating occasions over the course of four days prior to attending their study visit. It is estimated that participants will spend approximately 2 hours completing the food diary over the course of 4 days. Levels of process-modified protein consumed will be calculated using food composition tables and the NOVA classification system for processed foods. Participants will attend a single study testing visit at which they will provide a fasting urine (mid-stream, first-void) sample and blood sample (approx. 30 mL). Participants will also complete surveys in relation to their demographics, physical activity level (International Physical Activity Questionnaire (IPAQ)) and mood (Centre for Epidemiological Studies Depression scale (CES-D) and Spielberger State Trait Anxiety Inventory (STAI)). It is estimated that it will take participants approximately 40 minutes to complete these surveys.
Sponsors
Prof Louise Bennett
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Body mass index between 18.5 and 35 kg/m2
Exclusion criteria
Diagnosed with an inflammatory bowel disease (e.g. Ulcerative colitis, Crohn’s disease) Any dramatic dietary changes in the past 3 months (e.g. becoming vegetarian, starting a restrictive diet) Taking anti-depressant or anti-anxiety medication Pregnant or breastfeeding
Outcome results
None listed