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The effect of a 12-week low carbohydrate vs a high carbohydrate weight loss diet on oxidative stress and inflammation in New Zealand defence force personnel.

The effect of a 12-week low carbohydrate vs a high carbohydrate weight loss diet on oxidative stress and inflammation in New Zealand defence force personnel.

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621000481875
Enrollment
42
Registered
2021-04-23
Start date
2021-07-01
Completion date
2021-07-15
Last updated
2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a 12-week RCT to investigate three key metabolic markers in the weight loss context using two different dietary approaches: a conventional low fat approach (LF) and a carbohydrate restricted approach. The markers are: i. F2 prostanes, a marker of oxidative stress; ii. the ratio of omega 6 to omega 3 polyunsaturated fats, specifically arachinonic acid (AA) to eicosapentanoic acid (EPA); iii. , and iii. blood glucose patterning. Other outcomes will be body composition, weight, waist circumference, and visceral fat, The hypothesis is that the carbohydrate-restricted group will show a higher AA to EPA ratio, a reduced F2 isoprostane (oxidative) response and a more even blood sugar pattern compared to the low fat group.

Interventions

This randomised controlled trial (RCT) is a 12-week dietary intervention comparing a low carbohydrate, high fat (LCHF) way of eating with a control mainstream-nutrition-guided group in a group of navy personnel from the New Zealand Defence Force (NZDF). The LCHF diet is defined as <130g carbohydrates per day; 15-25% of total energy from protein; >60% of total energy from fat. Participants will be required to consume 3 meals a day (or the addition of more meals as long as it does not exceed their

This randomised controlled trial (RCT) is a 12-week dietary intervention comparing a low carbohydrate, high fat (LCHF) way of eating with a control mainstream-nutrition-guided group in a group of navy personnel from the New Zealand Defence Force (NZDF). The LCHF diet is defined as <130g carbohydrates per day; 15-25% of total energy from protein; >60% of total energy from fat. Participants will be required to consume 3 meals a day (or the addition of more meals as long as it does not exceed their energy threshold) for 12 weeks. Participants will be expected to prepare their own food but will be provided with detailed instructions / resources / recipes to assist them. Resources provided to them will be a combination of those designed specifically for this research, and associated websites for recipes and other information (www.ditchthecarbs.com and www.dietdoctor.com). The dietitian and nutritionist will be administering the intervention. Participants will be required to track their dietary intake for a 2-week period at two time-frames (weeks 1-3, and weeks 6-8) on a free smart phone app called Easy Diet Diary. This will be sent to the research team who has access to the partner application, Foodworks for analysis. Research assistants that are nutrition-trained will be undertaking group sessions with participants every two weeks, where they will use food frequency questionnaires to measure adherence.

Sponsors

Auckland University of Technology
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

Navy personnel that are over 125kg and are registered on the FIT for LIFE programme with the NZ Defence Force

Exclusion criteria

Less than 125 kg Not on the FIT FOR LIFE programme Pregnant or breastfeeding females

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026