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MYSS-HYPE: A pilot study of contingency management for smoking cessation in young people with Borderline Personality Disorder features

MYSS-HYPE: A pilot open-label study of the safety and acceptability of contingency management for smoking cessation in young people with Borderline Personality Disorder features

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621000424808
Enrollment
11
Registered
2021-04-16
Start date
2021-04-26
Completion date
2023-06-09
Last updated
2024-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this pilot study is to investigate whether Contingency Management (CM) is acceptable and safe as an intervention for smoking cessation in young people with Borderline Personality Disorder (BPD) features. Existing patients of Orygen's HYPE clinic (N=40) between the ages of 15 and 25 (inclusive) will receive eight weekly sessions of CM in an open-label pilot study, with assessments at baseline, week 8, and follow-up at 16 weeks. The primary hypotheses are that CM will be an acceptable and safe intervention for cigarette smoking in young people with BPD features.

Interventions

All participants will undergo eight weeks of Contingency Management (CM). The CM will incentivise abstinence from cigarette smoking using cash reinforcement. Participants will attend 8 short (15 minute) face to face sessions in which they will report on their past week cigarette smoking and complete a carbon monoxide breath test (using a Smokerlyzer device). Participants submitting CO tests indicative of abstinence will receive a cash reward. The cash reward available at each session will increa

All participants will undergo eight weeks of Contingency Management (CM). The CM will incentivise abstinence from cigarette smoking using cash reinforcement. Participants will attend 8 short (15 minute) face to face sessions in which they will report on their past week cigarette smoking and complete a carbon monoxide breath test (using a Smokerlyzer device). Participants submitting CO tests indicative of abstinence will receive a cash reward. The cash reward available at each session will increase with each consecutive week of abstinence, beginning at $25 (Week 1) and increasing in five-dollar increments up to a maximum of $60 (Week 8). Participants who have smoked in the past week will not receive a cash reward in their weekly session; furthermore, the potential reward for abstinence will reset at the starting amount ($25) the following week. In total, participants may receive up to $340 in cash rewards for verified abstinence throughout the trial. Session attendance checklists will be used to monitor adherence to the intervention and research procedures. Concomitant Therapy As patients of Orygen Specialist Program, participants will also continue to receive Treatment As Usual (TAU), i.e., standard psychosocial and psychiatric care delivered at the Orygen Specialist Program. TAU may include the opportunity to discuss cigarette smoking cravings and smoking cessation with their treating team (i.e., a mental health clinician and psychiatric registrar/consultant psychiatrist), in addition to a referral to Quitline. Participants may also undergo clinically indicated pharmacotherapy. Participants discharged from the Orygen Specialist Program, and enrolled at the Orygen Primary Services (Orygen Clinical Trials Unit) site will receive TAU at a mental health outpatient service.

Sponsors

Orygen
Lead SponsorCharities/Societies/Foundations

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
15 Years to 25 Years
Healthy volunteers
No

Inclusion criteria

Aged 15-25 years old (inclusive); Receiving mental health care at Orygen Specialist Program or other mental health outpatient service; Presenting with 3 or more BPD features; Report smoking at least 5 cigarettes per day for at least 5 days per week within the past four weeks, confirmed by a CO > 5ppm on Smokerlyzer; Fluent in the English language; and Able to give informed consent and adhere to study procedures.

Exclusion criteria

Have used smoking cessation medications within the last week; Already engaged with Quitline at the time of consent; Have a diagnosis of first episode psychosis and/or psychological disturbance such that they will be unable to comply with the study protocol.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026