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Effect of sugammadex on the serum plasma levels of circulating oestrogens and progesterones in healthy females who take hormone contraception in the perioperative setting

Effect of sugammadex on the serum plasma levels of circulating oestrogens and progesterones in healthy females who take hormone contraception in the perioperative setting

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12621000409875
Enrollment
122
Registered
2021-04-15
Start date
2021-02-19
Completion date
2021-11-23
Last updated
2021-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Lab studies suggest that sugammadex can reduce plasma oestrogen and progesterone concentrations to the equivalent effect of 1 missed dose of the pill. However, there has been no investigations of this in real life patients.

Interventions

Pre-menopausal women between 18-50 years old who are undergoing a planned operative procedure, are on a hormone contraceptive, and receiving 1 dose of IV sugammadex (dose variable based as determined by treating anaesthetist) will have 3 serum samples (time = 0min, 15min, 240min post-sugammadex) taken to assess the change in serum oestrogen and progesterone. Note: time for sugammadex = 0 minutes can be anytime prior to administration of sugammadex. Timing of sugammadex administration is at end o

Pre-menopausal women between 18-50 years old who are undergoing a planned operative procedure, are on a hormone contraceptive, and receiving 1 dose of IV sugammadex (dose variable based as determined by treating anaesthetist) will have 3 serum samples (time = 0min, 15min, 240min post-sugammadex) taken to assess the change in serum oestrogen and progesterone. Note: time for sugammadex = 0 minutes can be anytime prior to administration of sugammadex. Timing of sugammadex administration is at end of the procedure though timing will vary depending on each case and treating anaesthetist. The eligibility of participants will be based on a questionnaire if they are likely to receive sugammadex in their procedure. There are no changes to a patient's anaesthetic regimen as determined by their treating anaesthetist (i.e. they would receive sugammadex regardless if participants were enrolled in the study).

Sponsors

Dr. Tamblyn Devoy
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

- Pre-menopausal females 18-50 years old undergoing a planned procedure

Exclusion criteria

- Male participants - Females <18 years old or >50 years old - Post-menopausal women - Incomplete/missing detail in questionnaire form - Missed oral contraceptive pill in the past week - New medroxyprogesterone depot given within the last <3 weeks [due to peaked concentration]

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026