None listed
Conditions
Brief summary
The primary aim of this study is to determine whether peripheral blood flow differs according to the approach used to prescribe training pressures for blood flow restricted exercise (BFRE). A secondary aim is to explore associations between self-reported tolerability and cuff pressures. The specific research questions posed for this study of older adults are: 1) Does peripheral blood flow rate after cycling differ between cuff pressure prescription approaches? 2) Are sensations of discomfort, breathlessness and tightness intensity related to cuff pressure? We hypothesise that in older adults: 1) Peripheral blood flow rate will be significantly lower when the cuff is inflated and higher following cuff release when percent of systolic blood pressure, perceived cuff tightness or an arbitrary pressure are compared to the recommended percent of limb occlusion pressure (LOP) approach for prescribing blood flow restricted training pressure. 2) Significant positive associations will exist between cuff pressures and a) sensations of peripheral muscle discomfort and tightness under the cuff during cuff occlusion and b) intensity of breathing discomfort upon cuff release.
Interventions
In this experimental study, each participant will experience four experimental conditions, randomised over two days (two conditions each day; two 90-minute sessions separated by 48 hours each). In each experimental condition, participants will perform five minutes of low intensity cycling (9-11 on the Borg Rating of Perceived Exertion Scale), using a portable cycling pedal (Dual Exercise Bike, Bodyworx, Australia) while seated in an upright chair. Prior to and during cycling, participants will h
In this experimental study, each participant will experience four experimental conditions, randomised over two days (two conditions each day; two 90-minute sessions separated by 48 hours each). In each experimental condition, participants will perform five minutes of low intensity cycling (9-11 on the Borg Rating of Perceived Exertion Scale), using a portable cycling pedal (Dual Exercise Bike, Bodyworx, Australia) while seated in an upright chair. Prior to and during cycling, participants will have an inflatable cuff (Achedway, Australia) placed on the proximal portion of both thighs, which will be inflated to a pre-specified pressure dependant on the experimental protocol. There will be a 10-minute rest interval between each experimental condition conducted on the same day. Experimental conditions: Four different approaches to lower limb blood flow restriction will be used. For each of the four conditions, prescription of pressure in the inflatable cuffs (Achedway, Australia) placed on the proximal portion of both thighs will differ depending upon the experimental condition where: Approach 1 (Control) = 50% of limb occlusion pressure; Approach 2 = perception of cuff tightness (rating of 7 on a 0-10 scale where 0 means ‘Not tight at all’ and 10 means ‘Unbearable tightness’); Approach 3 = pressure calculated as 1.3 x systolic blood pressure measured at rest on day one; and Approach 4 = standardised pressure of 160 mmHg. The intervention will be delivered face-to-face in a laboratory at the City East Campus of University of South Australia by a physiotherapist with four years of clinical experience with older individuals, and more than five years of experience with blood flow restricted exercise (BFRE) in the research setting. We will record adherence to intervention using a session attendance checklist.
Sponsors
University of South Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Participants will be eligible for inclusion in this study if they are 50 years of age or greater.
Exclusion criteria
Participants will be excluded from the sample if have an ankle-brachial index (ABI) <0.9 or >1.4 or body-mass index (BMI) >30 Kg/m (assessed at the first visit) or self-report mobility issues limiting exercise performance or known contraindications or precautions to BFRE including major surgery within six months, use of oral contraception, family history of coagulation disorders, pulmonary embolism or deep vein thrombosis, a prior diagnosis of peripheral vascular disease, uncontrolled hypertension, Crohn’s disease, past fracture of the hip, pelvis, or femur.
Outcome results
None listed