None listed
Conditions
Brief summary
Kawakawa (Piper excelsum) is endemic to New Zealand, where it is widely used for food, therapeutic and traditional ceremonial purposes by Maori. Kawakawa leaves and fruits are reported to contain various active compounds including phenylpropanoids: myristicin, elemicin, piperine; lignans: diayangambin; and amides: piperchabamide, which are shown to possess therapeutic properties and are utilised for a wide range of health conditions not only limited to skin diseases but for the treatment of genitourinary, gastrointestinal as well as respiratory diseases. Despite the traditional use of kawakawa and its use in commercial products, no studies have been conducted to examine whether kawakawa would impact postprandial glucose metabolism, an important factor responsible for the development of type 2 diabetes (T2DM) and cardiovascular disease (CVDs). Therefore, we aim to examine the effects of kawakawa tea ingestion on postprandial glucose flux using a human randomized controlled intervention
Interventions
This study will examine the postprandial glycaemic response after an acute (single) ingestion of either water or kawakawa tea (4g per 250ml of hot water). As previously reported (1), the postprandial state lasts for approximately 4-5 h post-meal period. Participants under the supervision of the clinical coordinator will complete a screening assessment and, if eligible for entry into the trial, will be required in fasted condition to consume either a kawakawa tea infusion (4g per 250ml of hot wat
This study will examine the postprandial glycaemic response after an acute (single) ingestion of either water or kawakawa tea (4g per 250ml of hot water). As previously reported (1), the postprandial state lasts for approximately 4-5 h post-meal period. Participants under the supervision of the clinical coordinator will complete a screening assessment and, if eligible for entry into the trial, will be required in fasted condition to consume either a kawakawa tea infusion (4g per 250ml of hot water) or only hot water within 10 minutes based on their randomisation schedule. Following the intervention, a high glycaemic breakfast containing two slices of white bread, along with 15g of fruit jam and 250ml of rice milk, will be provided after 30 minutes, and participants will be asked to finish within 10 minutes. Blood will be sampled at regular intervals following their visit in fasting state at 0 min and then postprandial following tea or hot water at 30, 45, 60, 90, 120, 180 mins from a cannula inserted into an arm vein. Urine samples will be collected in a fasting state at 0 min, and then 0-4hrs urine will be collected postprandial following tea or hot water consumption. Since this is a two-arm, two-way cross over study, the participants will be required to come again for the intervention after a washout period of at least 48hrs. References 1. Monnier L, Colette C. Target for glycemic control: concentrating on glucose. Vol. 32 Suppl 2, Diabetes care. 2009.
Sponsors
Liggins Institute, The University of Auckland
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
• Gender: both males and females. To control for menstruation cycle variation in results, female participants would be required to come in the same phase of their cycle for both the intervention visits. • Age: 18-45 yr. • BMI: 18-25 kg/m2 • Non-smokers • Self-reported not consuming dietary supplements • No medical conditions
Exclusion criteria
Participants will be excluded from participation if they: • Are taking dietary supplements or herbal remedies which may affect the study outcome • Are allergic to pepper, nutmeg or similar spices • Are diagnosed with gastrointestinal disease (i.e. celiac, Crohn’s, colitis, etc.) or pre-existing metabolic disease • Are currently taking medications expected to interfere with normal digestive or metabolic processes including proton pump inhibitors, laxatives, etc. • Have used antibiotics within the previous one month or were on long-term antibiotic therapy. •Have a medical history precluding a healthy state: a history of myocardial infarction, angina, stroke, cancer or pre-existing diabetes.
Outcome results
None listed