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Graft Patency and Clinical Outcomes Following Coronary Artery Bypass Grafting with Instrumented Radial Arteries

Graft Patency and Clinical Outcomes Following Coronary Artery Bypass Grafting with Instrumented Radial Arteries

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12621000257864
Enrollment
294
Registered
2021-03-10
Start date
2021-09-01
Completion date
2022-08-10
Last updated
2024-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Our study is designed to evalute the patency rates and clinical outcomes in patients using an instrumented radial artery for coronary artery bypass grafting. An instrumented radial artery is one where an invasive coronary angiogram has been performed by inserting wires and catheters through the radial artery in to the heart. It is possible that this procedure may injure the radial artery and make it less useful as a bypass graft. In recent years, there has been an increasing preference for using arteries as bypass grafts in coronary artery bypass grafting, and invasive coronary angiograms are now routinely performed via the radial artery. Therefore, there is an increasingly common scenario of deciding whether the instrumented radial artery should be used as a bypass graft, and there is very little evidence to guide this decision. Our study will retrospectively identify patients who underwent CABG with instrumented radial arteries. We will then compare their outcomes to patients who did not have an instrumented radial artery used as a graft. Additionally, a subset of patients will undergo CT coronary angiograms. CT coronary angiograms look for narrowings in the blood vessels that supply the heart, without the need for catheters to be inserted. We will compare the narrowings / blockages in the instrumented radial artery with non-instrumented radial arteries, internal mammary arteries and saphenous vein grafts to determine whether instrumented radial arteries become blocked more quickly. Our hypothesis is that instrumented radial arteries have lower patency rates, and therefore higher rates of graft failure, then non-instrumented radial arteries, when used for coronary artery bypass grafting

Interventions

This study has two aims: 1. To evaluate the patency of instrumented radial arteries used for CABG, compared to non-instrumented radial arteries. 2. To evaluate the clinical outcomes of patients undergoing CABG with an instrumented radial artery, compared to those without an instrumented radial artery. Initially, patients will be recruited from the hospitals cardiac surgery database. Patients in the database who underwent surgery between January 2015 and December 2019 will be reviewed. Only tho

This study has two aims: 1. To evaluate the patency of instrumented radial arteries used for CABG, compared to non-instrumented radial arteries. 2. To evaluate the clinical outcomes of patients undergoing CABG with an instrumented radial artery, compared to those without an instrumented radial artery. Initially, patients will be recruited from the hospitals cardiac surgery database. Patients in the database who underwent surgery between January 2015 and December 2019 will be reviewed. Only those patients who had coronary artery bypass grafting with bilateral radial arteries will be included. For eligible patients, baseline data will be collected retrospectively from the hospital medical records and the hospital cardiac surgery database. Further data may be retrieved from other medical practitioners involved in their care. Information collected includes medical history, investigation results, pre-operative data, operation records, post operative data and longer term outcomes (see below for specific outcome data). Following review of the medical records, patients will be telephoned to seek clarification and further information as required. This will be a one off phone call, and will include facilitating completion of a Seattle Angina Questionnaire (short form, SAQ-7). The second part of the study, known as "patency follow up", involves conducting CT-coronary angiograms on a specific subset of patients. These patients are those who have an instrumented radial artery used as a coronary artery bypass graft. During the above "clinical follow up" phone call, patients will be assessed as to whether they are eligible for the "patency follow up" arm of the study. Eligible patients (see inclusion and exclusion criteria elsewhere in this document) will undergo a CT-coronary angiogram to evaluate the patency of the coronary artery bypass grafts. If eligible and willing to participate, patients will expect to undergo the CT-coronary angiogram within approximately 6-weeks. This scan will occur in Heidelberg, Victoria at I-MED Warringal and it is expected that the participant would require to be present for 1.5 - 2 hours duration.

Sponsors

A/Prof Omar Farouque
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Whole study: Adult patients aged 18 years or older who underwent coronary artery bypass grafting between 2015-2019 using bilateral radial arteries as conduits. For the Patency arm of the study (Aim 1): Patients who underwent CABG with an instrumented radial artery.

Exclusion criteria

Patency follow up (Aim 1) - Stage 4 or more chronic kidney disease. - Patients who have had either an invasive coronary angiogram or CT coronary angiogram following surgery. - The CABG operation record does not specify the location of each radial artery (ie which RA is grafted to which native vessel). - Allergy to contrast agent. - Unable to sufficiently control heart rate to perform scan or contraindication to metoprolol administration if required Clinical follow up (Aim 2) - Unable to provide consent

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 6, 2026