None listed
Conditions
Brief summary
This study will provide important evidence around how reducing sedentary behaviour in the evening by regularly performing short bouts of resistance activity may improve postprandial metabolism and sleep, both of which are important for cardio-metabolic health. We will conduct a randomised, crossover study involving 30 participants from across the BMI range. The study will include two experimental intervention sessions: uninterrupted sitting in the evening and sitting interrupted by regular activity breaks, separated by a minimum of six days washout period. Blood samples will be collected intermittently throughout the two intervention sessions and will be used to measure postprandial glucose, insulin and triglyceride responses. Sleep duration, efficiency and onset latency will be measured via accelerometer, and glucose control measured by continuous glucose monitoring during the 48 h after the intervention sessions. Mixed model regression will be used to examine differences in the effect of the two interventions.
Interventions
Participants will complete, in a random order, two, 4 h intervention sessions from 6 pm to 10 pm and one ~15 min introductory session. Each sessions will be separated by a minimum of six days. All sessions will be held at the University of Otago and will be conducted by an Assistant Research Fellow. A session attendance checklist will be collected so monitor participant movement through the intervention components.
Introductory Session:
The introductory session will take place at least seven da
Participants will complete, in a random order, two, 4 h intervention sessions from 6 pm to 10 pm and one ~15 min introductory session. Each sessions will be separated by a minimum of six days. All sessions will be held at the University of Otago and will be conducted by an Assistant Research Fellow. A session attendance checklist will be collected so monitor participant movement through the intervention components. Introductory Session: The introductory session will take place at least seven days prior to the first 4h intervention session. During the introductory session, participants will have the opportunity to ask any questions they might have. A participant booklet will be provided and explains. This will contain information about the study, research team contact details and space to record session dates and times. Blood pressure, weight and height measurements will be taken. The regular activity breaks video which will be used during the 4h intervention sessions will be shown to each participant; they will have the opportunity to practice the movements and form will be corrected if required. A wrist worn accelerometer will be given to the participant as well as a sleep and wear time diary (which will be explained). Participants will be instructed to wear the accelerometer for seven consecutive days. Lastly, participants will be scheduled for their two 4h evening sessions. The two intervention sessions are as follows: 1. Uninterrupted sitting: Participants will remain seated for the duration of the session while streaming their choice of entertainment on a device. 2. Sitting interrupted by regular activity breaks: Participants will complete a 3 min activity break every 30 min throughout the 4 h intervention session. At all other times they will remain seated and will stream their choice of entertainment on a device. During each 4 h intervention session participants will be provided with a standardised dinner (of beef curry, rice and naan bread with margarine spread) at baseline and dessert (of boysenberry slice) at 120 min. Test meal serving sizes will be calculated using the Schofield equation to determine each participants estimated energy requirement (EER). To ensure dietary intake is standardised during the day before the arrive for the intervention/control session standardised meals for breakfast (of cereal, milk, yoghurt and orange juice), morning tea (of caramel slice), lunch (of chicken noodle soup, ciabatta bread with margarine spread and cheese) and an optional snack (oaty slice bar) will be provided. All meals will need to be consumed prior to 2pm on the day of the 4 h intervention session.
Sponsors
Meredith Peddie
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used) (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
To be eligible for inclusion participants must be a non-smoker, self-report spending, on average, >5 h per day and >2 h in the evening engaged in sedentary behaviour and must not be taking any medication or dietary supplement that impact postprandial metabolism for example, metformin and/or niacin.
Exclusion criteria
This study requires participants to complete short bouts of physical activity, therefore participants will be excluded if physical activity is not medically appropriate (all participants will be screened using the Physical Activity Readiness Questionnaire prior to the study). If participants have been told by a medical professional that they should avoid physical activity, they will be excluded. Lastly, participants with an intolerance or allergy to dairy or gluten will be asked not to participate as the test meal includes these food items.
Outcome results
None listed