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Impaired right ventricular deformation to predict acute kidney injury in patients having heart surgery

Right ventricular strain calculated using perioperative trans-oesophageal echocardiography to predict acute kidney injury in patients receiving cardiopulmonary bypass for cardiothoracic surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12621000215820
Acronym
RVS-HIS
Enrollment
263
Registered
2021-03-03
Start date
2021-01-04
Completion date
2021-01-29
Last updated
2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This research project is investigating how a right ventricular strain, also known as deformation, obtained during trans-oesophageal echocardiography, may be used to predict kidney failure in patients who are placed on cardiopulmonary bypass for heart and lung surgery. Right ventricular strain may be calculated from echocardiographic images, already taken during heart surgery. Trans-oesophageal ultrasound is an established bedside ultrasound investigation that is used on most patients having heart and lung surgery. Recent technological advancements have allowed us to look at the heart in more detail with the aim of improving the outcomes of these patients. Kidney failure is a major problem after heart and lung surgery and increases post-operative mortality. It also results in longer hospital stays, invasive investigations, invasive treatments, and may result in the patient needing long term dialysis and transplantation. Our understanding of how right ventricular strain relates to kidney dysfunction is currently very poor. This research project will improve our understanding and our aim is that this will enable us to direct treatments to preserve kidney function in at risk patients and improve the burden of kidney failure on the patients affected and on the hospitals taking care of them.

Interventions

This study is a retrospective analysis of previously captured echocardiographic images of the right ventricle obtained from peri-operative trans-oesophageal echocardiography at the completion of cardiothoracic surgery once patients have been separated from cardiopulmonary bypass. These images are used to determine a numerical value for right ventricular strain. The source of images is from the database of trans-oesophageal echocardiography images obtained as part of the normal care of patients

This study is a retrospective analysis of previously captured echocardiographic images of the right ventricle obtained from peri-operative trans-oesophageal echocardiography at the completion of cardiothoracic surgery once patients have been separated from cardiopulmonary bypass. These images are used to determine a numerical value for right ventricular strain. The source of images is from the database of trans-oesophageal echocardiography images obtained as part of the normal care of patients that have undergone cardiac surgery requiring cardiopulmonary bypass at Fiona Stanley Hospital, Perth, WA, Australia between 3rd February 2020 to 3rd August 2020.

Sponsors

Heart and Lung Research Institute Western Australia
Lead SponsorCharities/Societies/Foundations

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

o Are greater than 18 years old o Have received cardiothoracic surgery involving cardiopulmonary bypass at Fiona Stanley Hospital in 2020 o Have received a transoesophageal echo as part of their usual care.

Exclusion criteria

No images available as determined by the two trained echocardiographers.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026