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Investigating the Efficacy of Peripheral intravenous catheter (PIVC) insertion using Imaging technology compared to Combined palpation and visualization for first-time insertion success. The EPIC randomised controlled trial.

A parallel-group, superiority randomised control trial (RCT) conducted in children aged 0-18 years of age will investigate the efficacy of ultrasound guided PIVC insertion compared to landmark technique to increase first attempt PIVC insertion success.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621000206820
Acronym
EPIC
Enrollment
164
Registered
2021-02-26
Start date
2021-07-08
Completion date
2023-01-10
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Most children receiving inpatient care at the Queensland Children's Hospital will require the insertion of a PIVC. Two thirds of healthcare consumers describe peripheral intravenous catheter (PIVC) insertion, as the ‘worst’ thing to happen during hospital admission, describing it as painful, frustrating and stressful. Despite their importance, PIVCs can be hard to insert with unacceptably high rates of first attempt insertion failure reported. This study aims to determine the efficacy of ultrasound guided PIVC insertion compared to landmark technique to increase first time insertion success in children aged <18 years.

Interventions

Ultrasound-guided PIVC insertion is the use of ultrasound to locate and select an appropriate vein, with the PIVC inserted under direct ultrasound visualization by advancing the needle into the vein whilst moving the ultrasound probe in the direction of needle advancement. The procedure takes approximately 10 minutes and is performed by specialist practitioners such as vascular access specialists, anaesthetists and paediatric registrars trained in this procedure. Protocol adherence will be mon

Ultrasound-guided PIVC insertion is the use of ultrasound to locate and select an appropriate vein, with the PIVC inserted under direct ultrasound visualization by advancing the needle into the vein whilst moving the ultrasound probe in the direction of needle advancement. The procedure takes approximately 10 minutes and is performed by specialist practitioners such as vascular access specialists, anaesthetists and paediatric registrars trained in this procedure. Protocol adherence will be monitored by the nurse assisting the procedure.

Sponsors

Griffith University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator)

Eligibility

Sex/Gender
All
Age
0 to 18 Years
Healthy volunteers
No

Inclusion criteria

1. Between 0- 365 days and 18 years of age 2. The treating team have indicated that the patient will require intravenous therapy 3. Informed consent to participate 4. Conscious for insertion of PIVC 5. Inpatient at Queensland Children's Hospital

Exclusion criteria

1. Non-English speakers without an interpreter 2. Children under care of department of communities or without a legal guardian 3. Patient receiving end-of-life care 4. Previous enrolment in this study 5. Previously documented high-risk Difficult Intravenous Access (DIVA)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026