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Safety and Efficacy of a single or multiple intra-articular injections of hyaluronic acid in osteoarthritis.

Safety and Efficacy of a single or multiple intra-articular injections of hyaluronic acid in osteoarthritis.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12621000098831
Enrollment
653
Registered
2021-02-01
Start date
2019-01-04
Completion date
2019-12-23
Last updated
2023-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The patients from which this data will be drawn were referred to the clinic by their general practitioner with symptomatic joint osteoarthritis for whom injection of hyaluronic acid (Durolane) was found to be the most appropriate treatment. This data is collected on all patients undergoing such injections as a routine pre and post injection measures of their pain and function. For those who had more than one injection, the time in days between injections will be analysed. Patient data will be included in the analyses if they were >18 years old with painful hip osteoarthritis and mild to moderate radiological changes on their imaging. There was no maximum age limit applied to the inclusion criteria. There were no specific inclusion or exclusion criteria in regards to race and gender. The current data set of the patient cohort intended for analysis was collected over 4 years.The data from these patients who have recieved Durolane injections in normal clinical practice will be analysed retrospectively.

Interventions

Data was obtained from patients who had treatment between January 2016 and December 2017 from patients who had received a single injection of hyaluronic acid (HA) (Durolane; and from patients who had had two or more injections up to December 2019. 3ml preparation) in accordance with the manufacturer’s guidelines as a part of their treatment with their surgeon or sports physician. This was performed according to standard hip injection technique with the patient supine using aseptic technique unde

Data was obtained from patients who had treatment between January 2016 and December 2017 from patients who had received a single injection of hyaluronic acid (HA) (Durolane; and from patients who had had two or more injections up to December 2019. 3ml preparation) in accordance with the manufacturer’s guidelines as a part of their treatment with their surgeon or sports physician. This was performed according to standard hip injection technique with the patient supine using aseptic technique under ultrasound guidance. A sterile 21 g spinal needle was used with infiltration of 2-3 mls of lignocaine 2% (Xylocaine, Astra Zeneca, UK) sub-cuticularly and on the hip capsule. Durolane 3mls was then injected intra-articularly.

Sponsors

Joint Health Institute
Lead SponsorCharities/Societies/Foundations

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients who have had one or more Durolane injections for osteoarthritis between January 2016 and December 2019

Exclusion criteria

1. Patients presenting with severe (Kellgren-Lawrence grade 4) OA, 2. inflammatory arthropathy 3. avascular necrosis.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 14, 2026