None listed
Conditions
Brief summary
Anastomotic leakage (AL) is a serious complication of intestinal surgery, resulting in increased morbidity and mortality. This study aims to explore the simple and non-invasive approach of measuring the enzymes amylase and lipase in the drain fluid following a low extra-peritoneal anastomosis to detect AL at an early stage in the post-operative recovery. The hypothesis is based on the premise that luminal content of the colon is high in amylase and lipase and that drain fluid levels will rise above the normal serum reference range when an AL occurs. Who is it for? You may be eligible for this study if you are aged 18 or older, you have undergone a low or ultra low colorectal operation without a diverting loop ileostomy, and have had placement of a rectal tube and a pelvic drain at surgery. Patients undergoing the above surgical operations for any indication will be eligible for this study. Study details All participants enrolled in this study will have a sample of drain fluid collected daily from their surgical drain whilst the pelvic drain is in place. Insertion of pelvic drains is an element of the standard of care following colorectal surgery. It is hoped this research will determine whether enzymes such as amylase and lipase in fluids drained from an intestinal surgical site can indicate whether a patient has experienced an AL from their intestinal join following surgery, at an earlier time point than when diagnosed based on clinical signs.
Interventions
Measure amylase levels in drain fluid daily after low colorectal anastomoses as an early indicator of anastomotic leak.
- a small sample of drain fluid will be collected daily while pelvic drain is in situ during hospital admission following colorectal surgery and samples will be sent to the local pathology service for measurement of amylase
- the amylase levels in drain fluid at each collection while the drain is in-situ will be collected and correlated to the clinical course
- clinical
Measure amylase levels in drain fluid daily after low colorectal anastomoses as an early indicator of anastomotic leak. - a small sample of drain fluid will be collected daily while pelvic drain is in situ during hospital admission following colorectal surgery and samples will be sent to the local pathology service for measurement of amylase - the amylase levels in drain fluid at each collection while the drain is in-situ will be collected and correlated to the clinical course - clinical course following surgery will be observed during admission (and data collected after patient has been discharged, retrospective data collection). - Follow up consultation at 6 weeks following surgery
Sponsors
Holy Spirit Private Hospital Northside
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Low and ultra low colorectal surgery without a covering loop ileostomy Placement of a rectal tube Placement of a pelvic drain at surgery Any indication requiring low pelvic colorectal anastomosis
Exclusion criteria
Age less than 18 years Inability to give consent
Outcome results
None listed