Relative contribution of trends in cardiovascular disease event rates and case fatality to declines in mortality: an international population-based comparative study

Relative contribution of trends in cardiovascular disease event rates and case fatality to declines in mortality during 2002 to 2015: an international retrospective population-based comparative study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12621000026820

Enrollment

3000000

Registered

2021-01-14

Start date

2017-01-09

Completion date

2017-01-09

Last updated

2021-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in developed countries. Although CVD mortality rates have declined markedly over the past 3 decades, the burden remains high in many countries, and the rising prevalence of obesity and diabetes may impact on these trends. Some conditions such as coronary heart disease and stroke are significant contributors to the burden of CVD mortality. Previous international studies such as the WHO-led MONICA study investigated the contribution of changes in case fatality and event rates to trends in myocardial infarction related mortality. No recent studies have provided international comparisons across these important measures. The results of this study will show how effective changes in treatment and prevention for CVD are at a whole-population level, and the ability to compare these data across countries enhances interpretation of the relative contributions of each.

Interventions

Observational. All people experiencing a cardiovascular disease (CVD) hospitalisation or death between 1st January 2002 and 31st December 2015 in England, New South Wales (Australia), New Zealand, and Ontario (Canada) will be identified. Person-linked administrative health datasets from each jurisdiction will be used for identification of all specified CVD events. Specified CVD events include myocardial infarction, acute stroke, coronary heart disease, cerebrovascular disease, and a grouping for

Eligibility

Sex/Gender

All

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

All hospitalisations and deaths which meet the specific requirements for each condition, based on International Classification of Disease coding, diagnosis or cause of death fields, and time period (admissions and deaths occurring between 01 January 2002 and 31 December 2015).

Exclusion criteria

Criteria will be imposed which exclude patients with low probability of a major cardiovascular event, such as short length of stay and elective admissions for acute events such as myocardial infarction or stroke.

Outcome results