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Measured energy expenditure in critically ill adult patients

Measured energy expenditure in critically ill adult patients: a retrospective analysis of 10 years of indirect calorimetry data in an Australian Intensive Care Unit

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12621000007831
Acronym
MEASURE
Enrollment
629
Registered
2021-01-08
Start date
2018-10-16
Completion date
2019-07-31
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Indirect calorimetry is a device used to measure energy requirements by measuring oxygen use and carbon dioxide production. Indirect calorimetry is the recommended method of guiding energy provision in critically ill patients in key nutrition guidelines. However, indirect calorimetry is not widely available in Australia and there is minimal data describing measured energy expenditure during Intensive Care Unit (ICU) admission in a modern setting. The primary aim of this study is to describe measured energy expenditure in adult mechanically ventilated critically ill patients in a modern Australian ICU.

Interventions

Indirect calorimetry measures resting energy expenditure by quantifying inspired oxygen and expired carbon dioxide and is the recommended method of guiding energy provision in critically ill patients in key nutrition guidelines. However, indirect calorimetry is not widely available in Australia and there is minimal data describing measured energy expenditure during Intensive Care Unit (ICU) admission in a modern setting. Study design: Retrospective single-centre observational study conducted at

Indirect calorimetry measures resting energy expenditure by quantifying inspired oxygen and expired carbon dioxide and is the recommended method of guiding energy provision in critically ill patients in key nutrition guidelines. However, indirect calorimetry is not widely available in Australia and there is minimal data describing measured energy expenditure during Intensive Care Unit (ICU) admission in a modern setting. Study design: Retrospective single-centre observational study conducted at The Alfred ICU, Melbourne, Australia. Population: Critically ill adult (=> 18 years) mechanically ventilated patients who had at least one indirect calorimetry measurement in the first 28 days of ICU admission at The Alfred between January 2010 to July 2019 will be considered for inclusion.

Sponsors

Dr Emma Ridley
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Critically ill adult (=> 18 years) mechanically ventilated patients who had at least one indirect calorimetry measurement in the first 28 days of ICU admission at The Alfred between January 2010 to July 2019 will be considered for inclusion.

Exclusion criteria

Indirect calorimetry measurements will be excluded if: • The duration of measurement was <5 minutes; • Measurements were conducted during treatment with therapeutic hypothermia or extracorporeal membrane oxygenation; • The average respiratory quotient for the measurement was <0.67 or >1.3 or; • The coefficient of variation (CV) for VO2 was >50%.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026