None listed
Conditions
Brief summary
We do not fully understand why Type 2 Diabetes (T2D) risk is, disproportionately higher in people from culturally and linguistically diverse backgrounds. Because of this knowledge gap, opportunities for early intervention are reduced and more lives will be lost. This study will identify if impaired non-fasting lipid metabolism is an early feature of T2D risk in Chinese immigrants in Australia. The metabolic phenotype of Chinese immigrants at risk of T2D is distinct from other ethnic groups. People from China develop T2D at a lower body mass index (BMI) and younger age than Caucasians. Traditional Western-based screening measures may not adequately capture the risk factors for T2D in this population. Chinese immigrants are Australia’s largest group of non-English speaking migrants. Recent evidence supports assessment of lipid profiles in T2D risk assessment in Chinese populations. We propose this mechanistic study as the first step in addressing the knowledge gap. We will conduct an acute high fat meal challenge to assess post-prandial lipid metabolism in Chinese adult participants. A group of age-matched Caucasian participants will be recruited as a comparison and we will employ a cross-over design. Each participant will attend two testing days, the first where they will be given a high-fat meal challenge and then second where they will be given a high-carbohydrate meal challenge. Aim: To demonstrate that Chinese-immigrants at risk for T2D have (a) an exaggerated lipid response to a high fat meal challenge and (b) a unique lipid phenotype compared with Caucasians. Hypothesis: Chinese-immigrants will exhibit a different post-prandial lipid profile compared with age and weight-matched Caucasian controls.
Interventions
This will be a 2-armed crossover intervention trial. The aim of the intervention is to challenge the postprandial lipid metabolism participants to determine if there is a difference between Chinese and Caucasian participants.
Participants will be given two separate meal challenges.
The first will be a high-fat meal challenge (with approximately 53% fat, 40% carb, 6% protein) and the second (on a separate study visit) will be a high-carbohydrate meal challenge (70% carb, 24% fat and 6% protein
This will be a 2-armed crossover intervention trial. The aim of the intervention is to challenge the postprandial lipid metabolism participants to determine if there is a difference between Chinese and Caucasian participants. Participants will be given two separate meal challenges. The first will be a high-fat meal challenge (with approximately 53% fat, 40% carb, 6% protein) and the second (on a separate study visit) will be a high-carbohydrate meal challenge (70% carb, 24% fat and 6% protein) . Each meal challenge will include 2 meals per study visit (one at 0 hours and another at 4 hours). The second meal at each visit will reflect a standard fat and carbohydrate composition. Participants will be asked to fast for 12 hours prior to each visit and consume a standard low-fat meal the evening prior to the visit. The intervention will be delivered by a trained researcher accompanied by a trained nurse with expertise in cannula blood draws. Both interventions will be delivered face-to-face on two separate occasions over 7 hours. The intervention will take place at our lab facility with a minimum 1 week washout period between the two intervention sessions.
Sponsors
Catherine Huggins
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject)
Eligibility
Sex/Gender
All
Age
35 Years to 54 Years
Healthy volunteers
No
Inclusion criteria
Group 1: Adult migrants of Chinese ethnicity who screen at high risk of T2D according to the AUSDRISK tool. Group 2:Adult Caucasians who screen at high risk of T2D according to the AUSDRISK tool
Exclusion criteria
A confirmed diagnosis of T2D or a diagnosis of lipid-related disorder (e.g hypercholesterolemia, fatty liver); anyone on lipid lowering medication or other medications and smokers known to interfere with normal lipid metabolism. Participants with abnormal fasting triglycerides and fasting glucose above 7mmol/L(this is indicative of diabetes)
Outcome results
None listed