None listed
Conditions
Brief summary
We are performing a cross-sectional and longitudinal analysis of airway oscillometry after lung transplantation. We aim to define airway oscillometry indices in patients who are: Stable, have acute lung allograft dysfunction, baseline lung allograft dysfunction and chronic lung allograft dysfunction. We are interested to define early airway closure and elastic recoil properties of the lung allograft.
Interventions
Two separate cohorts will be enrolled:
1. Cross-sectional Cohort: One single airway oscillometry will be performed for any patient presenting to the lung clinic > 3 months after lung transplantation. This cohort will attend a single observation session of approximately 30 minutes duration. Participants will be observed during a single study visit of no more than 30 minutes with no further observation
2. Longitudinal Cohort: Measurement of airway oscillometry indices, spirometry and lung volumes
Two separate cohorts will be enrolled: 1. Cross-sectional Cohort: One single airway oscillometry will be performed for any patient presenting to the lung clinic > 3 months after lung transplantation. This cohort will attend a single observation session of approximately 30 minutes duration. Participants will be observed during a single study visit of no more than 30 minutes with no further observation 2. Longitudinal Cohort: Measurement of airway oscillometry indices, spirometry and lung volumes with plethysmography will be performed at regular intervals after Lung Transplantation: At 3 months, 6 months and 12 months after transplant. This cohort will attend a three observation sessions of approximately 45 minutes duration. Participants will be observed during 3 study visits of no more than 45 minutes each. Airway oscillometry details: Participants will be asked to complete both an impulse oscillometry measurement and a spirometry assessment. Both tests involve breathing into a piece of equipment for 20-30 seconds whilst wearing a nose clip. Within an observation session three 30 second repetitions will be performed with a 30 second break in between each. The observation sessions will be performed by research assistants trained in the performance of lung function testing and airway oscillometry.
Sponsors
St Vincent's Hospital Darlinghurst
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
We will recruit all post-operative lung transplant recipients who present to the hospital for routine surveillance over a 24 months period. Patients will be identified as appropriate for the study by the primary investigators. Written informed consent will be obtained by the primary investigators and study coordinators at each site.
Exclusion criteria
Subjects will be excluded if they have a significant language barrier, pain or physical disability at the time of testing.
Outcome results
None listed