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Investigating resistance training in people living with psychotic disorders.

Resistance training versus aerobic interval training in a rehabilitation setting for people living with psychotic disorders: a randomised controllled trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12620001309976
Enrollment
54
Registered
2020-12-04
Start date
2020-12-09
Completion date
2023-10-23
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

People with chronic psychotic disorders experience functional disability, poor physical health and incomplete recovery that can be poorly responsive to first line treatments. Research has clearly demonstrated mental and physical health improvements from exercise, however predominantly utilising aerobic protocols. There is scant evidence regarding resistance training in people with psychotic disorders, even though preliminary evidence suggests safety and preference for this type of training. We will recruit participants with chronic psychotic disorders from three mental health rehabilitation units and randomise participants to resistance training, or control (aerobic- moderate intensity interval training), three supervised sessions per week for 8 weeks in a randomised controlled trial in which outcome assessors will be blind to condition allocation. The primary aim of this study will be to investigate the feasibility and acceptability of resistance training (recruitment, retention and participation). Secondary aims will include a comparison of various mental and physical health outcomes between exercise types pre and post the intervention. We hypothesise that resistance training will be feasible and acceptable to people with psychotic disorders.

Interventions

Participants randomised to the intervention will be engaged in supervised resistance training (repetitive strength activities using hand weights suitable to a small clinic gym) three times per week for 8 weeks, 45 minutes per session. This will include a 10 minute warm up and 5 minute cool down. Volume will be progressed to 40 minutes of active exercise by week 4 of the intervention, with total duration including warm up and cool down 55 minutes. Participants will be supervised by an accredited

Participants randomised to the intervention will be engaged in supervised resistance training (repetitive strength activities using hand weights suitable to a small clinic gym) three times per week for 8 weeks, 45 minutes per session. This will include a 10 minute warm up and 5 minute cool down. Volume will be progressed to 40 minutes of active exercise by week 4 of the intervention, with total duration including warm up and cool down 55 minutes. Participants will be supervised by an accredited exercise physiologist (AEP). They will participate in one to one sessions, in the small clinic gym of the mental health residential rehabilitation facility, the community care unit (CCU) in which they reside. The intensity of the intervention will be moderate in intensity, and will be calculated by conducting a 12 repetition maximum test (12-RM) for relevant large muscle groups - ie squat, bench press, bicep curl, and then via an established conversion calculator, Brzycki 1-RM Formula, 1-RM = Weight x (36 / (37 – Repetitions). The aim will be to increase muscle strength progressively over the 8 weeks. Training will be appropriate for beginners and be aimed at moderate intensity (40-70%) of estimated maximum strength, (1-RM). Week 1 will start with 40% of 1-RM, and progressed with 5% increments each week as per capacity of the individual, with 3 sets of 8-10 repetitions. Approximately six to eight exercises across main muscle groups used in activities of daily living were prescribed per session until a total of 30 minutes of active exercise was completed, or 40 minutes once the volume progressed in week 4. Six exercises across main muscle groups used in activities of daily living will be prescribed per resistance training session. As strength increases, sessions will be progressed using heavier weights, however each participant will be monitored for their response to training, and progression individualised. A typical session will include 6 exercises that target main muscle groups such as lower legs, back, arms/shoulders, and core, using a variety of standard resistance training equipment, for example; hand weights, kettle bells, resistance bands and a chest press bar and floor mat. An intervention session will involve whole body exercises that can be conducted using hand weights in a small clinic gym and hence easily replicated. Intervention sessions will be separated by a day to allow recovery in-between (ie Monday, Wednesday, Friday). A typical session is as follows: Sumo Squat Calf raises Bicep curl Crunches Row – theraband or hand weights Chest press All exercises are appropriate for resistance training in untrained participants and will be supervised by the AEP employed at each site. The content and weights of each session will be recorded using standard AEP protocol. Attendance will be recorded in a spreadsheet. Adverse events will be recorded, and addressed as per standard injury management protocol for the exercise program at the facility. Both exercise conditions (RT and control) will be aimed at moderate intensity exercise that will be balanced for total number of sessions and volume. The total volume of activity in RT was estimated to match what would have been attained if assigned to the AIT and in line with previous research protocols comparing aerobic with RT interventions in this population.

Sponsors

Dr Nicole Korman
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years
Healthy volunteers
No

Inclusion criteria

Patients will be invited to participate in the study if they meet all of the following criteria: 1. Aged between 18-64 years (inclusive) 2. Fulfil the DSM 5 criteria for schizophrenia and related psychotic disorders (any psychotic spectrum disorder such as schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depressive disorders with psychosis) as confirmed by the treating psychiatrist of the unit. 3. Have a treatment plan such that they are likely to reside within the CCU for the duration of the 8-week study 4. Agree to participate, has capacity to consent and able to follow the study instructions and procedures. 5. Has been cleared to participate in an exercise program by the accredited exercise physiologist (AEP) within the service, following standard assessment of suitability and risk as per AEP exercise guidelines within the CCU’s.

Exclusion criteria

Potential participants will be excluded if: 1. They are pregnant 2. They have a comorbid eating disorder in which exercise is considered to be contraindicated by the treating psychiatrist of the unit (ie anorexia nervosa where BMI <18; presence of medical complications of an eating disorder; or anorexia or bulimia nervosa is comorbid with exercise addiction) 3. Substance abuse is considered to be interfering with rehabilitation engagement, and their ongoing suitability for rehabilitation is under review by the treating team. 4. Inability to follow the study instructions and procedures

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026