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Micronutrient intake from enteral nutrition in critically ill adult patients

Micronutrient INTake from Enteral nutrition in critically ill adult patients expressed as a percentage of the Australia and New Zealand Nutrient Reference Values: a retrospective observational study (The MINT-E Study)

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12620001044910
Acronym
The MINT-E Study
Enrollment
57
Registered
2020-10-15
Start date
2020-08-17
Completion date
2020-09-13
Last updated
2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

When people are critically ill and require treatment in an Intensive Care Unit, they are often unable to eat food. In this situation the standard treatment is to supply them with food dripped into their stomach or bowel through a feeding tube (termed enteral nutrition). Enteral nutrition provides both macronutrients (carbohydrates, protein and fat) and micronutrients (vitamins, minerals and trace elements). In Australia, enteral nutrition formula composition is guided by the National Health and Medical Research Council (NHMRC). These standards, termed Nutrient Reference Values (NRVs), include the recommended dietary intake (RDI), adequate intake (AI) and upper level of intake (UL). However, there is very little information on the amount of micronutrients delivered to critically ill patients during Intensive Care Unit admission. We are conducting a retrospective observational study to assist in determining the micronutrient intake of vitamins B12, D, C, A, iron, folate, thiamine, zinc, and selenium delivered from enteral nutrition to critically ill adults admitted to Box Hill Hospital Intensive Care Unit (ICU), Melbourne, Australia between January 2018 and January 2020. Micronutrient intake will be assessed for the first seven days of ICU admission and compared to Australian NRVs.

Interventions

Enteral nutrition (EN) is the most preferred and common mode of nutrition provision in mechanically ventilated critically ill patients. Feeding formulas used for EN aim to provide complete nutrition in the form of both macro- and micronutrients. In Australia, the micronutrient composition of EN formulas is guided by standards established for a healthy population by the National Health and Medical Research Council (NHMRC). These standards, termed Nutrient Reference Values (NRVs), include the reco

Enteral nutrition (EN) is the most preferred and common mode of nutrition provision in mechanically ventilated critically ill patients. Feeding formulas used for EN aim to provide complete nutrition in the form of both macro- and micronutrients. In Australia, the micronutrient composition of EN formulas is guided by standards established for a healthy population by the National Health and Medical Research Council (NHMRC). These standards, termed Nutrient Reference Values (NRVs), include the recommended dietary intake (RDI), adequate intake (AI) and upper level of intake (UL). Limited information is available on the micronutrient intake of critically ill patients receiving EN during routine clinical practice in the Intensive Care Unit (ICU). The aim of this retrospective observational study is to determine daily micronutrient intake of vitamins B12, D, C, A, iron, folate, thiamine, zinc, and selenium delivered from EN to critically ill adults admitted to Box Hill Hospital Intensive Care Unit (ICU), Melbourne, Australia between January 2018 and January 2020. Micronutrient intake will be assessed daily for the first seven days of ICU admission and compared to NRVs. There will be no participant involvement, only access to patient medical records.

Sponsors

Dr Emma Ridley
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Inclusion criteria • Admitted to Box Hill Hospital ICU • Aged 18 years or older • Mechanically ventilated for at least the first 48 hours of ICU admission • Prescribed EN in the first 48 hours of ICU admission

Exclusion criteria

Exclusion criteria • Patients who received supplemental oral intake at the same time as EN at ICU admission or within the first 48 hours • Patients who received parenteral nutrition (PN) support at the same time as EN at the start of ICU admission or within the first 48 hours • Patients who are admitted for palliative care and/or organ donation, are made palliative or die within the first 7 days of ICU admission

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026