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Transvenous Cardiac Implantable Devices and Pulmonary Hypertension: An Echocardiographic Evaluation in a Cohort Study

Transvenous Cardiac Implantable Devices and Pulmonary Hypertension: An Echocardiographic Evaluation in a Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12620000999932
Enrollment
1572
Registered
2020-10-06
Start date
2020-07-21
Completion date
2020-07-21
Last updated
2020-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Previous case studies have shown that intracardiac lead thrombus can cause pulmonary embolism (PE). However, the incidence of new or worsening pulmonary hypertension after cardiovascular implantable electronic devices (CIED) lead placement has not been well investigated. Pulmonary hypertension after CIED implantation will subsequently result in right heart failure and increase morbidity and mortality. This study is aimed to: I. Determine the incidence and factors associated with development of pulmonary hypertension and right ventricular dysfunction in patients with CIEDs. II. Determine the role of anticoagulation in the prevention of pulmonary hypertension in patients with CIEDs.

Interventions

Participants who have previously had a transvenous cardiac device implanted between 2009 to 2017 will be followed up with an annual echocardiogram up to 10 years post-cardiac device implantation, to investigate pulmonary artery pressure.

Sponsors

Centre for Heart Rhythm Disorders, University of Adelaide
Lead SponsorUniversity

Eligibility

Sex/Gender
All
Age
18 Years to 99 Years
Healthy volunteers
No

Inclusion criteria

1. All patients who underwent CIED implantation between 2009 and 2017 will be reviewed for inclusion 2. The eligible participants will only be identified from a single centre (Centre for Heart Rhythm Hospital/Royal Adelaide Hospital) 3. The control participants are the age-matched patients who have not had a CIED implanted but who have had an annual echocardiogram follow-up

Exclusion criteria

- patients without any follow-up of at least two echocardiograms (first within 6 months and the second greater than 1 year following implant)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026