Transcutaneous Pulse Oximetry Brain Monitoring Study

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The T-POT study will assess a brain pulse oximeter designed to non-invasively monitor brain oxygen and brain blood flow in patients requiring acute neurological monitoring in the hospital or intensive care unit (ICU) with acute brain injury or at high risk of acute neurological deterioration. It is known that patients with an acute brain injury are at risk of neurological deterioration, typically as a result of low blood flow in the minutes, hours or days after the initial injury. Available brain monitoring is highly invasive and therefore only used in the most severe cases. An accurate non-invasive method to monitor brain oxygen levels and brain blood flow would facilitate monitoring in more patients and earlier detection and treatment of acute neurological deterioration. This could improve healthcare outcomes, reducing both long-term disability and death. The T-POT pulse oximetry technology can monitor oxygen levels and blood volume changes in organs of the body, including the brain. The sensor and algorithms of the Brain Pulse Oximeter were developed to overcome limitations of conventional pulse oximeters that only provide oxygen and a photoplethysmogram (PPG) signal from blood flow in the skin. The PPG detects blood volume changes in the microvascular bed of a tissue. The major aim of the study is to assess the correlation of the brain pulse oximeter oxygen levels with invasively measured cerebral perfusion pressure (CPP).