None listed
Conditions
Brief summary
This case-control study aims to identify whether correcting serum parathyroid hormone (PTH) after parathyroidectomy would have an effect on the clinical criteria for frailty, which are highly prevalent in older persons suffering from primary hyperparathyroidism (pPTH). Women (60 and older) undergoing neck exploration for pHPT will be assessed for general functional parameters (gait, balance, and muscle power and strength) and clinical criteria for frailty (Fried’s criteria) before and after (3 months) surgery. Women of the same age undergoing neck exploration for benign nontoxic goiter will serve as controls. This study will provide a new understanding of the role of PTH in the pathophysiology of frailty. We will also identify novel potential interventions to prevent frailty, falls and fractures in high-risk older persons with alterations in their calciotropic hormones.
Interventions
Surgery - Parathyroidectomy . The cases will undergo parathyroidectomy within a month of the first review for the study. Parathyroidectomy is the procedure involving surgical removal of one or more of the parathyroid glands. The procedure can be done under general anaesthesia or local anaesthesia. The incision is usually made just under the larynx and the oofending glads are located. The duration of the surgery depends o the complexity and could range from 30 minutes if straightforward versus ho
Surgery - Parathyroidectomy . The cases will undergo parathyroidectomy within a month of the first review for the study. Parathyroidectomy is the procedure involving surgical removal of one or more of the parathyroid glands. The procedure can be done under general anaesthesia or local anaesthesia. The incision is usually made just under the larynx and the oofending glads are located. The duration of the surgery depends o the complexity and could range from 30 minutes if straightforward versus hours if there are any complications. Minimally invasive procedures are becoming increasingly popular.
Sponsors
AIMSS - University of Melbourne
Study design
Allocation
Non-randomised trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Women (60 years and older) undergoing neck exploration for pHPT Women of the same age undergoing neck exploration for benign nontoxic goiter will serve as controls.
Exclusion criteria
malignant/toxic goitres; males ; age<60yrs
Outcome results
None listed