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Assessing the role of conjunctival and lid margin sensitivity has in ocular discomfort

To investigate the sensitivity of the conjunctiva and lid margin to cold stimuli and determine the repeatability of sensitivity measurement using the Liquid Jet Aesthesiometer (LJA)

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12620000761965
Enrollment
30
Registered
2020-07-27
Start date
2020-08-21
Completion date
2020-10-31
Last updated
2020-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The research study aims to investigate the sensitivity of the eyelid margin and the conjunctiva (a thin layer on the white part of your eye) using an instrument called the Liquid Jet aesthesiometer, which uses small drops of saline to stimulate your eye. Participants will be invited to take part in this study to help us better understand what the role the conjunctiva and lid margin have in eye discomfort, and to analyse the repeatability of this new instrument.

Interventions

Brief name: Air Jet Stimulation of the Conjunctiva and Lid Margin Brief Description: Different parts of the eyes have different sensitivities and contribute to ocular discomfort in different ways. By using a machine which causes air jet stimulation of certain sites of the eye, the sensitivity of the structure can be determined and linked to the level of ocular discomfort they experience. The machine is attached to a slit lamp bio-microscope where a subject places their chin and forehead onto t

Brief name: Air Jet Stimulation of the Conjunctiva and Lid Margin Brief Description: Different parts of the eyes have different sensitivities and contribute to ocular discomfort in different ways. By using a machine which causes air jet stimulation of certain sites of the eye, the sensitivity of the structure can be determined and linked to the level of ocular discomfort they experience. The machine is attached to a slit lamp bio-microscope where a subject places their chin and forehead onto the attached rest. The participant is instructed to look a target in the room and the machine is manoeuvred and aimed at the appropriate site of the eye. Duration of observation: Each test to measure sensitivity will span approximately 10 minutes. With multiple repeats at different ocular sites, the time needed to complete the observation will be approximately 2.5 hours. There will be 1 repeat on the cornea, 3 repeats on the bulbar conjunctiva and 1 repeat on the lid margins. The session will be conducted and administered by final year optometry students under the supervision of A/Prof Blanka Golebiowski, Adj Professor Klaus Ehrmann and Professor Fiona Stapleton.

Sponsors

UNSW Australia
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Primary purpose
Diagnosis

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

18 to 40 years old Able to read and comprehend English Either a full-time soft contact lens wearer or do not wear contact lenses

Exclusion criteria

Have any eye or general health conditions which may affect your eyes, for example severe dry eye, active eye allergy, Graves’ disease, diabetes, Sjögren syndrome or multiple sclerosis Have any eye infections or inflammation Currently use eye and/or general medication which is known to affect eye health or eye comfort, such as chloramphenicol, prednisolone acetate, Accutane, antidepressant medications, topical glaucoma drops or anti-allergy drops Have any history of eye surgery like corneal refractive surgery or cataract surgery Wear soft contact lenses overnight or on an intermittent or part-time basis only Are a current or previous wearer of hard contact lenses, including Ortho-K lenses Are pregnant or breastfeeding

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026