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The effect of different types of medicine information on side effect reporting

The effect of different types of medicine information on side effects attributed to a placebo tablet

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12620000735954
Enrollment
116
Registered
2020-07-14
Start date
2020-07-14
Completion date
2020-09-30
Last updated
2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to investigate the effect of different types of medicine information on side effect reporting. It is hypothesised that people who receive an explanation of the nocebo effect will report fewer side effects and have improved mood compared to those who watch a negative news item about a medicine.

Interventions

Nocebo information: Participants randomised to this group will be shown a 4-minute animated video that explains how the nocebo effect occurs. Participants will be informed that when we are told about medicine side effects, we come to expect side effects and are more aware of our natural symptoms causing us to mistakenly attribute them to the medication. The video will be delivered on a computer before participants take a placebo tablet, during a 45-minute study session at the University of Auckl

Nocebo information: Participants randomised to this group will be shown a 4-minute animated video that explains how the nocebo effect occurs. Participants will be informed that when we are told about medicine side effects, we come to expect side effects and are more aware of our natural symptoms causing us to mistakenly attribute them to the medication. The video will be delivered on a computer before participants take a placebo tablet, during a 45-minute study session at the University of Auckland. The video will be delivered once and individually to each participant in this group. To ensure the researcher remains blinded to participant group allocation, they will not be in the room when participants watch the video.

Sponsors

Professor Keith Petrie
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Educational / counselling / training
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Participants must be 18 years of age or older, able to read and write in English.

Exclusion criteria

Participants will be excluded if they are taking any prescription medications, if they have epilepsy, diabetes, any liver or kidney disorders, or any heart problems.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026