None listed
Conditions
Brief summary
The primary aim of this study is to determine the feasibility of conducting an RCT of remifentanil versus fentanyl for opioid analgesic infusion in invasively ventilated patients who are expected to require mechanical ventilation for longer than 24 hours.
Interventions
Remifentanil infusion via intravenous route will be provided for a minimum duration of 24 hours and continued until the patient no longer requires mechanical ventilation.
Infusion rate will start at 6-9 mcg/kg/hr and be titrated by the ICU nurse as per the target Richmond Agitation-Sedation Scale (RASS), and assessment of pain and discomfort
Sponsors
Arvind Rajamani
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
a. Patient intubated and receiving mechanical ventilation b. Treating clinician expects that the patient will remain intubated until the day after tomorrow (unlikely to be extubated the following day) c. Patient requires immediate ongoing opioid analgesic infusion for comfort, safety, and to facilitate the delivery of life support measures
Exclusion criteria
a. Patient is pregnant and/or lactating b. Has been intubated (excluding time spent intubated within an operating theatre or transport) for greater than 12 hours in an intensive care unit c. Known sensitivity to any of the study medications or the constituents of the study medications
Outcome results
None listed