None listed
Conditions
Brief summary
Poor mental health has been identified as one of the main health problems among middle aged adults (National Mental Health Registry 2003). Polyphenols, which are a major antioxidants source, have been proven to be beneficial towards the prevention of various diseases including cancer and diabetes and more recently in mental health. The aim of this research is to determine the effectiveness of polyphenols-rich tropical fruit juice towards the improvement of mental health status. Subjects aged 45 to 59 years who had given consent to this research will be divided into 2 groups; supplementation and placebo groups. Subjects will be interviewed about personal and social information, medical history, lifestyles factors, dietary history questionnaire and food frequency questionnaire (polyphenols). Besides that, mental health status will also be assessed with several questionnaire. Anthropometric measurements and blood pressure will also be conducted. Polyphenols-rich tropical juice or placebo were given to subjects for 3 times a week (1500ml/day) for a period of 10 weeks. Blood test will be conducted at baseline and after supplementation period. A total of 10 mL of blood will be drawn by a trained phlebotomist during each blood test. Metabolomics analysis using urine samples will be conducted during baseline, week 5 and by the end of supplementation period.
Interventions
Middle-aged subjects with signs of poor mental health and cognitive status were randomly assigned to received either polyphenols-rich tropical fruit juice TP 3-in-1 (TM) or placebo. A total of 1500 ml/day (divided for 3 intakes per day) of polyphenols-rich TP 3-in-1 juice or placebo would be taken by the subjects for 3 times per week. Study was conducted for a total of 10 weeks. Changes on subjects' mental health and cognitive status was measured during baseline, week 5 and after the supplementa
Middle-aged subjects with signs of poor mental health and cognitive status were randomly assigned to received either polyphenols-rich tropical fruit juice TP 3-in-1 (TM) or placebo. A total of 1500 ml/day (divided for 3 intakes per day) of polyphenols-rich TP 3-in-1 juice or placebo would be taken by the subjects for 3 times per week. Study was conducted for a total of 10 weeks. Changes on subjects' mental health and cognitive status was measured during baseline, week 5 and after the supplementation ended. Additionally, measurement on oxidative stress and metabolic changes was measured throughout the intervention period. Researcher, who was a PhD candidate, would send the beverages on a weekly basis to the subjects' houses. Data collection during baseline, week 5 and by the end of intervention period was conducted at Clinical Trial Ward, UKM Medical Centre.
Sponsors
Suzana Shahar
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject)
Eligibility
Sex/Gender
All
Age
45 Years to 59 Years
Healthy volunteers
No
Inclusion criteria
Had poor score in at least three out of the seven categories of mental health (General Health Questionnaire-28) and cognitive status (as assessed using Rey Auditory Verbal Learning Test (RAVLT)
Exclusion criteria
1. Change of dietary habits for the past 3 months 2. Subjects with history of mental illness (Alzheimer's disease, schizophrenia, history of stroke) 3. Physical disability 4. Pregnant and lactating women 5. Women who are on hormone-replacement therapy 6. Subjects with chronic diseases (eg. diabetes, hypertension, hyperlipidemia, cancer etc) 7. Subjects who took any food supplements or/and regular polyphenols-rich fruits (more than 2 servings/day for the past 3 months prior to the study)
Outcome results
None listed