ADAPT - COVID-19 Study - A prospective, observational cohort study at St Vincent’s Hospital Sydney

ADAPT - COVID-19 Study - Characterising pathophysiological, immunological and clinical outcomes relating to COVID-19 infection in the patient population of St Vincent’s Hospital Sydney.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12620000554965

Acronym

ADAPT

Enrollment

120

Registered

2020-05-11

Start date

2020-05-14

Completion date

2023-07-01

Last updated

2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this observational study is to evaluate the effects of COVID-19 on the immune system, heart, lung, brain function and mental health of patients of St Vincent’s Hospital, Sydney. Patients will attend the hospital six times over the 12 months following their COVID-19 diagnosis to be monitored by their Doctor and to provide blood samples, collect swabs and complete questionnaires. Overall, the study will increase our knowledge to better understand how the body responds to COVID-19 and provide valuable information to improve care for people with this infection in the future.

Interventions

This is a prospective, observational cohort study of all patients at St Vincent’s Hospital Sydney who test positive for COVID-19 infection. The cohort will consist of two components. Cohort A - Mild disease patients recruited through the community cohorts Cohort B - Moderate-severe patients recruited through the inpatient service at St Vincent’s Hospital Sydney. Each patient shall be followed for a period of 12 months from the time of COVID-19 diagnosis. The study will run for 2 years in total. The study will examine the short, medium and long term effects of COVID-19 on the immune system. The study will also examine how the immune system responds to COVID-19 to form antibodies and the long-term effects of COVID-19 on heart, lung and brain function and also a person’s mental health and effect on a person’s activities of daily living.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age greater than or equal to 18 years 2. Confirmed SARS-CoV-2 by nucleic acid testing 3. Able to provide informed consent

Exclusion criteria

1. Unable or unwilling to provide consent 2. Death is deemed to be imminent and inevitable within the next 24 hours 3. Pregnancy (Cohort B only)

Outcome results