None listed
Conditions
Brief summary
Metabolic imbalances at the postprandial state, particularly after a high fat meal are important contributing factors to development of cardiovascular diseases. The underlying mechanisms involves a sharp increase in triacylglycerol, a pro-inflammatory response along with an aberrant production of pro-oxidant molecules, which may impair vascular and endothelial functions. A high fat meal challenge is a method to investigate such imbalances promoted in a daily basis in Western diets. This study aims to investigate if food anthocyanins are able to attenuate these deleterious effects of high fat meals. Participants attended fasted and had a high-fat meal with either 250 ml of queen garnet plum juice (intervention rich in anthocyanins) or apricot juice (control free of anthocyanins).
Interventions
On test days, participants attended fasted and had a high-fat meal together with either 250 ml of queen garnet plum juice (intervention) or apricot juice (control). The order of juice consumption was conducted by a researcher independent to the data collection using a computer generated randomization sequence. Blinding strategies included colouring of control juice, as well as advertising and consenting participants to a “stone fruit juice study” without providing information on which fruit was
On test days, participants attended fasted and had a high-fat meal together with either 250 ml of queen garnet plum juice (intervention) or apricot juice (control). The order of juice consumption was conducted by a researcher independent to the data collection using a computer generated randomization sequence. Blinding strategies included colouring of control juice, as well as advertising and consenting participants to a “stone fruit juice study” without providing information on which fruit was being investigated. The test meals consisted of 1 hash brown (62g) 2 beef chipolatas (90g), 1 croissant (168) served with unsalted butter (5g) and apricot jam (10g) and 2 scrambled eggs (2 x52g eggs, 30mL pure cream, 10g unsalted butter, 0.5g salt). Participant were requested to have the meal in 20 minutes. A serve of the queen garnet plum juice (intervention) was weighed as 200g of plum puree with 50mL of water added. Participants were contacted 6 pm on the previous day to ensure compliance with the fasting. It was request that their last meal would be at 8 pm (12 hours of fasting until the test breakfast). Participants could only drink water during that period. There was a wash-out period of 14 days between tests.
Sponsors
University of Wollongong
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
. Inclusion criteria: Older adults, male/female, aged over 55 years with the body mass index (BMI) over 25kg/m2.
Exclusion criteria
Exclusion criteria: current treatment or diagnosis of hypertension or diabetes; chronic liver or renal diseases; history of cardiovascular events; currently taking anti-inflammatory medication, aspirin or warfarin; smoking; diagnosis or self-reported gastrointestinal disorders; allergy to stone fruits or food colorants; impediment in having a full breakfast (English style) early in the morning (not suitable for vegetarians).
Outcome results
None listed