None listed
Conditions
Brief summary
The purpose of this project is to investigate the feasibility and preliminary efficacy of exercise to increase prostate tumour blood flow and oxygenation as a means to improve the effectiveness of radiotherapy. Who is it for? You may be eligible to join this study if you are a male aged 18 years or over, have a diagnosis of localised or locally advanced prostate cancer, and are scheduled to receive radiotherapy. Study details: Participants in this study will receive a supervised exercise intervention for the duration of their radiotherapy treatment (6-8 weeks). The exercise program involves aerobic and resistance exercises undertaken 3 times per week in an exercise clinic setting. The exercise sessions are 20-30 minutes in duration and take place immediately before radiotherapy treatment sessions. All participants will complete assessments at baseline (i.e. before starting radiotherapy) and after completion of their radiotherapy treatment in order to evaluate tumour oxygenation, treatment side effects, aerobic fitness and functional capacity, as well as health-related quality of life. Additionally, participants will undergo further assessments to evaluate tumour blood flow and immune cell mobilisation in response to single exercise sessions. It is hoped that exercise will be found to be feasible during radiotherapy treatment for prostate cancer patients and that this research will contribute important new information that will be useful to clinicians in the management of prostate cancer.
Interventions
Participants in this study will be allocated to an exercise group, in which men with prostate cancer undergoing radiotherapy will attend three clinic-based supervised exercise sessions each week, for the duration of their radiotherapy treatment (6-8 weeks), consisting of moderate- to high-intensity aerobic and resistance exercise. The supervised exercise sessions will be scheduled immediately before radiotherapy sessions. Each exercise session will take approximately 20-30 minutes to complete an
Participants in this study will be allocated to an exercise group, in which men with prostate cancer undergoing radiotherapy will attend three clinic-based supervised exercise sessions each week, for the duration of their radiotherapy treatment (6-8 weeks), consisting of moderate- to high-intensity aerobic and resistance exercise. The supervised exercise sessions will be scheduled immediately before radiotherapy sessions. Each exercise session will take approximately 20-30 minutes to complete and will be supervised face-to-face by an exercise physiologist with specific training in exercise for the management of cancer. Participants will receive a progressive aerobic and lower limb resistance exercise program. Aerobic exercise will be performed at 60-85% of age-predicted maximal heart rate (i.e. 220-age) for 10-15 minutes per session on a motorised treadmill, stationary cycle ergometer (upright and recumbent), or performing box step-ups, followed by resistance exercise training. Resistance exercise will be prescribed using repetition maximums (RM), where patients will be required to perform 3-4 different resistance exercises using major muscle groups of the lower limbs, at 6-12 RM (the maximal weight that can be lifted 6 to 12 times each set, equivalent to ~70-85% of 1RM) for 1-2 sets per exercise to achieve moderate-to-high intensity. Lower limb resistance exercises will include wall squats, stiff-leg deadlifts, leg extensions, and leg curls. To monitor exercise intensity, heart rate will be continuously recorded using a heart rate monitor with chest strap and blood pressure readings will be taken at rest and during the last minute of aerobic exercise as well as after leg extensions. In addition, exercise session intensity will be assessed with the Borg 10-point rating of perceived exertion scale. Exercise program adherence and compliance will be assessed through the use of attendance rates to supervised clinic sessions and percent of exercise session completed, specifically using exercise record sheets with prescribed programming variables to compare with actual versus completed components recorded.
Sponsors
Edith Cowan University
Study design
Allocation
Non-randomised trial
Primary purpose
Treatment
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Men diagnosed with localised or locally advanced prostate cancer who are scheduled to receive radiotherapy.
Exclusion criteria
(1) Previous or concomitant surgery or treatment for prostate cancer, except androgen deprivation therapy (2) Distant metastases (3) Contraindications to exercise training at moderate to vigorous intensity (4) Baseline activity levels of >150 min/week at moderate to vigorous intensity (5) Any uncontrolled medical condition (6) Body mass index (BMI) >35 kg/m2 (7) Contraindication to magnetic resonance imaging or contrast agent (8) Inability to walk 400 meters uninterrupted, unassisted, and pain-free
Outcome results
None listed