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The ROX index in the Emergency Department – predicting NIV failure: a prospective observational study

The ROX index in the Emergency Department – predicting NIV failure: a prospective observational study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12620000431921
Enrollment
113
Registered
2020-04-01
Start date
2019-11-18
Completion date
Unknown
Last updated
2021-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Through the calculation of routinely collected patient data, we hope this study will demonstrate a numerical value which can be used to predict the success or failure of non-invasive ventilation. This is a form of respiratory support given to patients who are short of breath.

Interventions

Non-invasive ventilation commenced in the emergency department, as practiced by emergency department clinicians. The researchers will collect routinely recorded patient observations (such as heart rate, respiratory rate, oxygen saturations) in addition to the routinely documented NIV settings, prospectively for any patient commenced on NIV in our ED in order to then calculate the ROX for each patient at specific time stamps. A waiver of consent has been granted from the local ethics committee as

Non-invasive ventilation commenced in the emergency department, as practiced by emergency department clinicians. The researchers will collect routinely recorded patient observations (such as heart rate, respiratory rate, oxygen saturations) in addition to the routinely documented NIV settings, prospectively for any patient commenced on NIV in our ED in order to then calculate the ROX for each patient at specific time stamps. A waiver of consent has been granted from the local ethics committee as the study does not intervene in routinely delivered treatment. Data from participants will be collected for the duration of their NIV usage, or until it is removed, or 12 hours - whichever may come first.

Sponsors

Liverpool Hospital Emergency Department
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

This pragmatic study will include all patients aged 18 or over who are commenced on NIV for breathlessness in the ED, as judged by the treating clinician, regardless of predicted underlying pathology. Breathlessness will be defined by the treating clinician, who will routinely use subjective markers of a patient’s work of breathing as part of clinical assessment, combined with objective data on gas exchange

Exclusion criteria

Prior advanced care directive specifying ’not for intubation’ Comorbidities & disease severity where clinician/family provide limitations of care (i.e. not for intubation or ICU) NIV utilised as a pre-oxygenation strategy with intention to intubate Patients electively intubated for diagnostic or therapeutic procedures, such as fibreoptic bronchoscopy and surgery

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026