None listed
Conditions
Brief summary
Arterial stiffness is a cardiovascular risk factor, which increases naturally with age. We and others have shown, that Kyolic garlic reduces arterial stiffness by improving the flexibility of arteries. We hypothesise that increased flexibility of arteries will lead to slower blood flow, increased oxygen uptake, and aerobic fitness. This 12 week RCT aims to assess the effect and dose-response of Kyolic garlic on arterial stiffness, lactate threshold, aerobic fitness, recovery, and cardiovascular proteomic biomarkers, in middle-aged endurance athletes with elevated arterial stiffness.
Interventions
Double-blind parallel randomised placebo-controlled dose-response trial of 12 weeks duration investigating the effect of two (participant ID 1-40) or four (ID 41-80) capsules of aged garlic extract (AGE) (Kyolic Reserve Formula containing 1.2g/2.4g AGE powder, 1.2mg/2.4mg SAC (2 or 4 capsules x 600 mg/0.6 mg SAC) on arterial stiffness and aerobic fitness during high intensity exercise in a group of middle-aged recreational endurance athletes.
The first half of participants will be allocated to 2
Double-blind parallel randomised placebo-controlled dose-response trial of 12 weeks duration investigating the effect of two (participant ID 1-40) or four (ID 41-80) capsules of aged garlic extract (AGE) (Kyolic Reserve Formula containing 1.2g/2.4g AGE powder, 1.2mg/2.4mg SAC (2 or 4 capsules x 600 mg/0.6 mg SAC) on arterial stiffness and aerobic fitness during high intensity exercise in a group of middle-aged recreational endurance athletes. The first half of participants will be allocated to 2 capsules daily (ID 1-40), the second half of participants (ID 41-80) will be allocated to 4 capsules daily. Compliance will be monitored by return of remaining investigational product/ trial capsules at 4-weekly intervals.
Sponsors
AProf Dr Karin Ried
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1) Elevated pulse wave velocity/arterial stiffness (>10% than average of reference values adjusted for age and gender) 2) Minimum exercise 3x30min/wk moderate to high intensity (E.g. triathletes, swimming, running, cycling)
Exclusion criteria
- Unstable other medical conditions or serious illness, e.g. CAD, dementia, terminal illness, recent bereavement, secondary hypertension, recent significant medical diagnosis, and pregnancy - Already taking daily garlic supplements
Outcome results
None listed