Deferred Cord Clamping to Reduce Need for Neonatal Blood Transfusion: the Transfusions In The APTS Newborns Study (TITANS)

Understanding the Role of Deferred Cord Clamping in Reducing Need for Neonatal Red Cell Transfusion: what can be learned from the Australian Placental Transfusion Study? A retrospective, nested, observational study of APTS newborns

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12620000195954

Acronym

TITANS

Enrollment

720

Registered

2020-02-19

Start date

2020-05-15

Completion date

Unknown

Last updated

2022-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The Australian Placental Transfusion Study (APTS) and other studies provide strong evidence that deferring umbilical cord clamping at birth for up to a minute is a simple, safe procedure that reduces the proportion of preterm infants who need a blood transfusion by 10%. The mechanism is not fully understood – but one potential mechanism is an increased volume of transfusion of blood from the placenta to the baby after birth. Alternatively, deferred cord clamping may reduce severity of illness in the first weeks after birth. This could lead to fewer blood tests, greater tolerance of anaemia, and better opportunities for babies to make their own red cells. The Transfusions In The APTS Newborns Study (TITANS) is designed is to obtain and analyse more data about the babies in APTS to investigate the mechanism behind the reduced need for red cell transfusions, and to explore whether there are other changes in clinical care that could reduce the need for transfusion.

Interventions

Data from the APTS study combined with other routinely collected clinical data from APTS Australian and New Zealand sites relating to receipt of transfusion and the factors that affect risk for transfusion in preterm infants during their hospital admission after birth will be used for this study. No additional participant contact is required for the study. Data will be collected from patient medical records.

Eligibility

Sex/Gender

All

Age

No minimum to 30 Weeks

Healthy volunteers

Inclusion criteria

Enrolled and randomly assigned newborns (>30 weeks gestation) in Australian and New Zealand sites for the Australian Placental Transfusion Study (APTS)

Exclusion criteria

APTS participants who withdrew participation from the study

Outcome results