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Investigating the effects of single chiropractic spinal manipulation on brain activity

Impact of specific vs non-specific high-velocity low-amplitude spinal manipulations on sensorimotor integration in chiropractic care in participants with neck pain, ache or stiffness

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12620000175976
Enrollment
96
Registered
2020-02-17
Start date
2020-02-19
Completion date
2020-03-20
Last updated
2021-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study endeavours to investigate how a single specific vs. non-specific chiropractic spinal manipulation changes brain activity. Therefore, the study hypothesis is that there is no difference between a specific versus a non-specific chiropractic spinal manipulation.

Interventions

The intervention will be a specific adjustment to the cervical spine using an Activator Instrument. Before the intervention, the principal investigator will first screen all the participants for inclusion. Then, a registered chiropractor will check for subluxated cervical segments. Eligible participants will attend a single data collection session lasting approximately an hour. Following inclusion, a pre-intervention assessment of somatosensory evoked potentials (SEP) will be undertaken by the p

The intervention will be a specific adjustment to the cervical spine using an Activator Instrument. Before the intervention, the principal investigator will first screen all the participants for inclusion. Then, a registered chiropractor will check for subluxated cervical segments. Eligible participants will attend a single data collection session lasting approximately an hour. Following inclusion, a pre-intervention assessment of somatosensory evoked potentials (SEP) will be undertaken by the principal investigator to assess the sensorimotor integration. The pre-intervention assessment will involve the application of electrical stimulation over the participant's wrist, to stimulate the median nerve, as they focus their gaze on a fixed target on the wall. During the stimulation, 1000 SEPs will be recorded via electroencephalography (EEG) cap placed on the participant's head. The chiropractor will then deliver the intervention comprising of specific high velocity, low amplitude spinal manipulation (HVLASM) to the cervical spine with the Activator Instrument. HVLASM is a form of manual therapy commonly used by chiropractors to restore the movement of the spinal joints. It is to emphasise here, that only one thrust will be applied. The activator instrument is a hand-held device that delivers fast, precise and low-force adjustment to the spine. Its use reduces the amount of variability in the thrust amplitude and duration. Overall, the specific HVLASM intervention will take five minutes. Immediately after the intervention, the participant's SEP will be re-assessed. All the assessments and intervention will be delivered as the participant comfortably sits on a chair.

Sponsors

New Zealand College of Chiropractic
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

All individuals with subclinical pain between the age of 18 and 50 years will be eligible. Individuals with subclinical pain defines them as having no severe pain-related problems but with the occurrence of repeating neurophysiological dysfunction such as mild neck pain, ache or stiffness. Participants may include students, staff, faculty, and previous patients of the college’s chiropractic centre. Participants will be eligible for inclusion if they are English speaking and have previously sought chiropractic care.

Exclusion criteria

People with subclinical pain having no detectable subluxation on the experimental day will be excluded. Other exclusion criteria are: people with a cardiac pacemaker or any metal plates on their skull and those who have had received chiropractic treatment less than a week before the experiment day.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026