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Do clinical and neurophysiological measures predict treatment response to manual therapy in patients with non-specific neck pain?

Do clinical and neurophysiological measures predict treatment response to manual therapy in patients with non-specific neck pain?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12620000163909
Enrollment
63
Registered
2020-02-17
Start date
2020-03-03
Completion date
2021-02-25
Last updated
2023-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary aims of the study are to establish: 1. The extent to which baseline measures of central nervous system hyperexcitability affect clinical outcome in patients with neck pain. 2. The extent to which clinical outcome is associated with the change in central nervous system hyperexcitability. The secondary aims will be to establish: 1. The extent to which patient expectation is associated with clinical outcome. The hypotheses are: 1. There will be an association between baseline measures of central nervous system hyperexcitability and clinical outcome in patients with neck pain. 2. Clinical outcome will be associated with the change in central nervous system hyperexcitability 3. Patient expectation will be associated with clinical outcome

Interventions

Participants will receive 4 sessions of 45 minutes (1 session per week) of manual therapy each, with the participant positioned in supine or prone. The clinician will be able to choose from the following manual therapy techniques according to their clinical reasoning: 1. Cervical passive mobilisations: oscillatory movements of the cervical vertebra 2. Soft tissue massage: massage over the neck musculature 3. Trigger point manual therapy: sustained pressure applied over symptomatic trigger point

Participants will receive 4 sessions of 45 minutes (1 session per week) of manual therapy each, with the participant positioned in supine or prone. The clinician will be able to choose from the following manual therapy techniques according to their clinical reasoning: 1. Cervical passive mobilisations: oscillatory movements of the cervical vertebra 2. Soft tissue massage: massage over the neck musculature 3. Trigger point manual therapy: sustained pressure applied over symptomatic trigger points Treatment will be delivered by a Physiotherapist at a primary care physiotherapy clinic. Attendance will be monitored with a session attendance checklist.

Sponsors

University of the Basque Country UPV/EHU
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

- Primary complaint of neck pain - Non-traumatic (insidious) history of onset - Mechanical in nature i.e. pain has clear mechanical aggravating and easing positions or movements (e.g. neck rotation and extension)

Exclusion criteria

- Neurological deficit (either sensory or motor) or radicular pain - Referral to other health professional to exclude red flags required - Widespread, non-anatomical/nonspecific distribution of pain; stimulus-independent spontaneous pain - Cold hyperalgesia - Whiplash injury - Have or are awaiting neck surgery - Inflammatory disease or spinal condition

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026