None listed
Conditions
Brief summary
Antioxidants are naturally-occurring compounds found in plant-derived foods and beverages, such as coffee. The antioxidants we are going to focus on in this study are the chlorogenic acids. These are a family of strong antioxidants present in coffee that may show some health benefits. The amount of chlorogenic acid intake in a typical diet is high and, for people who drink it, coffee is the major dietary source of these antioxidants. Coffee contains high levels of chlorogenic acids which consist of phenolic acids including caffeic acid, ferulic acid and dimethoxycinnamic acid. Dimethoxycinnamic acid (DMCA) is found at high levels in coffee, and is very well absorbed. It is found in the bloodstream just a few minutes after drinking. However, the final form in urine is a mystery. Since DMCA is only found in significant amounts in coffee, then if we could find the chemical form in urine, it could be a useful biomarker of coffee intake in populations. Knowing the chemical form would also allow us to define its pathway of metabolism.
Interventions
During the study day, participants will attend the research facility after an overnight fast and provide a fasted urine sample. Participants will also be asked to avoid coffee/coffee products for 10 hours prior to collection of this fasting urine sample. Following this, participants will be given a coffee to drink (4 g instant coffee in 150 mL hot water) by a dietitian or trained researcher. Participants will then continue collecting their own urine for the next 24 hours, into provided containe
During the study day, participants will attend the research facility after an overnight fast and provide a fasted urine sample. Participants will also be asked to avoid coffee/coffee products for 10 hours prior to collection of this fasting urine sample. Following this, participants will be given a coffee to drink (4 g instant coffee in 150 mL hot water) by a dietitian or trained researcher. Participants will then continue collecting their own urine for the next 24 hours, into provided containers. Participants are also asked to consume no more coffee during those 24 hours, but can otherwise eat and drink ad libitum. Participants returned their collected urine the following morning.
Sponsors
Monash University
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Adults able to provide informed consent.
Exclusion criteria
• Diagnosed medical conditions that affect the gastrointestinal tract or metabolism • Urinary tract infections or other conditions related to the bladder. • Any dietary allergies that prevent consuming coffee.
Outcome results
None listed