None listed
Conditions
Brief summary
Forty healthy adult subjects will be recruited to attend three data collection sessions at the CASS labs at Deakin University Burwood Campus. During any session, participants will be provided with any one mouth rinse in a random order: containing fatty acid (oleic acid 20mM), containing triglyceride (vegetable oil isocaloric to the fatty acid wash; positive control), or containing neither (negative control). They will then return to the lab after 90 minutes for an ad libitum buffet lunch, where they will be able to consume as much or as little food as they like. Food intake will be measured to assess the effect of the mouth rinse on intake. Participants will return to the CASS lab on separate days to complete the same methods, but with the other two remaining mouth rinses (cross-over design). Data will be collected via the researcher weighing food and plates to calculate the exact quantity of food intake. This will be performed in a separate room to the buffet to ensure there is no influence on the participants. Additional measures: • Participants will keep a food record of their intake on the morning of each session. This will be completed using an online tool – ASA24 Australia • Participants will complete satiety questionnaires before and after lunch to ensure they are comfortably full following buffet. These will be completed using an online survey software – Compusense Cloud The aim is to assess the effects of a fatty acid-based mouth rinse on acute appetite and ad libitum food intake. We hypothesise that the fatty acid-based mouth rinse will reduce food intake compared to a control rinse.
Interventions
The treatment is a 30 second mouth rinse of a solution containing 20 mM of oleic acid. The treatment will be provided as a single dose 90 minutes prior to the outcome measures.
Washout period between treatments/control treatments will be 7 days.
The treatment will be timed and observed by researchers to ensure that participants adhere to the entire mouth rinse protocol.
Sponsors
Dr Andrew Costanzo
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Ages 18-55 years, speaks fluent English, healthy
Exclusion criteria
Smoker, pregnant or lactating, allergic to foods that are served, restricted eater (as determined by the Three Factor Eating Questionnaire), adhering to a restrictive diet, dietary requirements or illnesses that prevents or interferes with eating (eg, Crohn's disease, diabetes).
Outcome results
None listed