None listed
Conditions
Brief summary
Even obesity and metabolic syndrome (MetS) are associated with colorectal neoplasia (CRN) and carcinoma (CRC), none of them is regarded as a criterion for the timing of first screening colonoscopy in guidelines. Incidences of CRNs in different age groups in bariatric surgery candidates will be compared by SC.
Interventions
Colonoscopy will be performed to the patients who will be included in the study. All procedures will be held by the same team who contributes to this trial. Bowel cleansing will be achieved by polyethyleneglycol or a phosphate-based solution depending on the renal function. Colonoscopy will be performed under general anesthesia and 1-2 mg/kg propofol following premedication with midazolam 0.05 mg/kg and fentanyl 1 µg/kg. The procedure takes about 20 minutes. All polyps will be resected utilizing
Colonoscopy will be performed to the patients who will be included in the study. All procedures will be held by the same team who contributes to this trial. Bowel cleansing will be achieved by polyethyleneglycol or a phosphate-based solution depending on the renal function. Colonoscopy will be performed under general anesthesia and 1-2 mg/kg propofol following premedication with midazolam 0.05 mg/kg and fentanyl 1 µg/kg. The procedure takes about 20 minutes. All polyps will be resected utilizing forceps or snares and will be sent for patholological examination. The same two pathologists will be responsible for the histologic examination. Polyp size will be measured in the laboratory and also colonoscopically, by comparison with a 6-mm forceps. Location of polyps will be recorded as proximal or distal with respect to the splenic flexure. Multiple polyps in both proximal and distal colon will be evaluated in diffuse category.
Sponsors
Mehmet Ali Yerdel
Study design
Allocation
Non-randomised trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Bariatric surgery candidate, average-risk for colorectal cancer. Average risk defines asymptomatic individuals lacking high-risk medical conditions (polyposis syndromes, inflammatory bowel disease) and a personal/family history of CRN/CRCs.
Exclusion criteria
Patients who had previous screening colonoscopy were excluded for standardization. Patients who were symptomatic (i.e.,bleeding, positive fecal occult blood test, changed bowel habits, iron deficiency anemia) or in "high-risk" category for colorectal cancer were also excluded as those who did not want to comply.
Outcome results
None listed