None listed
Conditions
Brief summary
The aim of this randomised controlled trial is to determine whether the use of a therapeutic dose of lignocaine enhances elective outpatient gastroscopy episodes as measured by time to eye opening, gastroscope insertion conditions, time from patient discharge from recovery and patient comfort (measured by a pain score). Hypothesis: Lignocaine is a local anaesthetic which may assist with improved endoscope insertion conditions, less post gastroscopy discomfort and faster time to wake-up and discharge from the post-anaesthetic recovery unit (PACU).
Interventions
Intervention group: 1.5mg/kg lignocaine/lidocaine to maximum dose of 120mg as a bolus dose, prior to gastroscopy, via intravenous administration, administered by anaesthetist.
The injection of the 'intervention drug' will be given prior to the induction drug of propofol, preferably as soon as IV cannula is inserted. If the gastroscopy is still proceeding after 20 minutes, a further dose of the 'intervention drug' will be given (either NaCl 0.9% or 1.5mg/kg of lignocaine not exceeding a total d
Intervention group: 1.5mg/kg lignocaine/lidocaine to maximum dose of 120mg as a bolus dose, prior to gastroscopy, via intravenous administration, administered by anaesthetist. The injection of the 'intervention drug' will be given prior to the induction drug of propofol, preferably as soon as IV cannula is inserted. If the gastroscopy is still proceeding after 20 minutes, a further dose of the 'intervention drug' will be given (either NaCl 0.9% or 1.5mg/kg of lignocaine not exceeding a total dose of 3mg/kg lignocaine). (Please note, patients who are having a simultaneous colonoscopy will not be included.) Strategies to monitor adherence: independent researcher to note that the 'intervention drug' (1x10ml syringe of 10ml NaCl 0.9% or lignocaine 1.5mg/kg up to maximum dose of 120mg bolus) is given prior to induction. A gastroscopy involves insertion of a gastroscope (a semi rigid telescope with a camera on the end) which is inserted by the gastroenterologist into the mouth and terminating in the small bowel via the stomach and oesophagus. This procedure usually done under sedation in Australia with the assistance of an anaesthetist. The procedure duration is usually under 10 minutes and rarely exceeds 30 minutes. For further information, please refer to this website:https://healthywa.wa.gov.au/Articles/F_I/Gastroscopy-endoscopy
Sponsors
Alfred health
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Adults (greater than or equal to 18 years) undergoing elective outpatient gastroscopy with low aspiration risk.
Exclusion criteria
1. Patient refusal 2 After-hours or emergency gastroscopies including indications for upper gastrointestinal bleed. 3 Contraindication or allergy to lignocaine. 4 <18 years old or >80 years old 5. Pregnant patients 6. Patients at high risk for aspiration or requiring intubation 7. Gastroscopy solely performed by topicalisation of the throat 8. Patients requiring opioids during gastroscopy
Outcome results
None listed