None listed
Conditions
Brief summary
The purpose of this study is to identify the time point of peak serum potassium levels during the reperfusion phase of adult liver transplantation. We aim to assess the the changes in blood potassium levels from baseline values during reperfusion, and evaluate clinical factors that may be associated with the development of hyperkalaemia. Who is it for? The study will include adult patients undergoing liver resection surgery. This is a retrospective study to test the hypothesis that the addition of intrathecal morphine (ITM) results in reduced postoperative opioid use and enhanced postoperative analgesia in patients undergoing open liver resection using a standardized enhanced recovery after surgery (ERAS) protocol with multimodal analgesia. Study details The aim of this study is to quantify the cumulative oral morphine equivalent daily dose in milligrams (oMEDD) in the postoperative period and evaluate maximum pain scores at rest and on movement after surgery. In addition, we will highlight the importance of using intrathecal morphine in patients undergoing liver resection. It is hoped that this study will be hypothesis generating and provide valuable data for power calculations for future studies on evaluating the use of intrathecal morphine in patients undergoing liver resection surgery.
Interventions
This is a retrospective analysis of morphine use and pain scores in adult patients who underwent major open liver resection between July 2010 and June 2017 using a standardized enhanced recovery after surgery protocol. All patients underwent surgery at the Austin Hospital, a university hospital in Melbourne, Australia with a dedicated high volume hepato-pancreatic-biliary and liver transplant centre. Eligible patients were identified by International Statistical Classification of Diseases (ICD)
This is a retrospective analysis of morphine use and pain scores in adult patients who underwent major open liver resection between July 2010 and June 2017 using a standardized enhanced recovery after surgery protocol. All patients underwent surgery at the Austin Hospital, a university hospital in Melbourne, Australia with a dedicated high volume hepato-pancreatic-biliary and liver transplant centre. Eligible patients were identified by International Statistical Classification of Diseases (ICD) codes that included the following surgical categories: i.) excision of lesion of liver, ii.) segmental resection of liver, iii.) lobectomy of liver, iv.) trisegmental resection of liver, and v.) segmental resection of liver for trauma. Patients were followed-up until hospital discharge for from the index admission.As this is a retrospective study, there is no patient involvement.
Sponsors
Austin Health
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All adult patients who underwent surgery at Austin hospital in Melbourne, Eligible patients were identified by International Statistical Classification of Diseases (ICD) codes that included the following surgical categories: i.) excision of lesion of liver, ii.) segmental resection of liver, iii.) lobectomy of liver, iv.) trisegmental resection of liver, and v.) segmental resection of liver for trauma.
Exclusion criteria
We will excluded patients with a history of chronic opioid use (defined as near-daily use of >60 mg oral morphine equivalent) for 8 weeks or longer and patients receiving epidural analgesia.
Outcome results
None listed