None listed
Conditions
Brief summary
This study aims to assess the cardiovascular risk in people with gout, through performing scanning the heart, and then performing the scan in 6 months. We will determine the impact of having an acute flare of gout on the scans, which is a surrogate of cardiovascular risk. This will help us understand the effect of acute inflammation on cardiovascular risk in gout,
Interventions
The exposure is an attack of acute gout.
We will do patient questionnaires, metrology(swollen and tender joint count), blood tests, a Coronary CT Angiogram. The total duration of follow-up for each patient is 6 months.
Patients will be assessed monthly, the first and last visit might last hour, the other visits will last about 20 minutes.
Sponsors
Fiona Stanley Hospital
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
A diagnosis of gout according to 2015 ACR criteria requiring allopurinol therapy 45 years and a minimum of 2 risk factors, i.e. controlled hypertension, controlled diabetes, controlled dyslipidemia, obesity, age >55 years, and first degree relative with evidence of atherosclerosis <65 years will be recruited.
Exclusion criteria
Other forms of inflammatory arthritis (especially rheumatoid arthritis and psoriasis Moderate to severe hepatic impairment moderate renal impairment Contra indication to allopurinol, especially azathioprine or 6-mercaptopurine use. Pregnancy or breastfeeding. Presence of any serious medical illness that may preclude follow up. Inability to provide informed consent
Outcome results
None listed