None listed
Conditions
Brief summary
The purpose of this study is the measure the effect of continuous positive airway pressure (CPAP) on the movement of thoracic and abdominal tumours. Who is it for? You may be eligible for this study if you are an adult who is receiving stereotactic ablative radiotherapy for any cancer in the abdominal or thoracic region. Study details All participants in this study will be asked to complete a radiotherapy simulation session where you will have a CT taken with and without CPAP. We will then measure your tumour motion from the imaging. If your tumour motion with CPAP is reduced, you will have this for your treatment sessions. We hope that CPAP will be a well-tolerated, effective method of reducing respiratory tumour motion. This will reduce the volume of healthy organs around the tumour receiving radiation.
Interventions
Continuous Positive Airway Pressure (CPAP) will be used in patients receiving stereotactic ablative body ratiotherapy (SABR) to any tumour in the lung or upper abdomen.
This will be delivered by sleep scientists, radiation therapists, radiation oncologists and medical physicists.
The patients will have CPAP at radiotherapy simulation session, in which a four dimensional computed tomography (4DCT) scan is acquired without CPAP, followed by a 4DCT acquired with CPAP. The simulation session will
Continuous Positive Airway Pressure (CPAP) will be used in patients receiving stereotactic ablative body ratiotherapy (SABR) to any tumour in the lung or upper abdomen. This will be delivered by sleep scientists, radiation therapists, radiation oncologists and medical physicists. The patients will have CPAP at radiotherapy simulation session, in which a four dimensional computed tomography (4DCT) scan is acquired without CPAP, followed by a 4DCT acquired with CPAP. The simulation session will take approximately 30 mins. The CPAP will be applied using room air, ramping up from 4 cmH2O to a maximum pressure of 20 cmH2O, depending on participant tolerance, over a period of 5 mins. The time between 4DCT acquisitions will be the CPAP pressure ramp up time, 5 mins. We will then measure the effect of CPAP on tumour motion based on the tumour visualised in the 4DCTs. If tumour motion is reduced with CPAP, the patient will have CPAP for the duration of each of their radiotherapy treatment sessions (1-5 sessions).
Sponsors
Peter MacCallum Cancer Centre
Study design
Allocation
Non-randomised trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age > 18 2. Has provided written informed consent for the trial 3. Receiving radiotherapy to an abdominal or thoracic tumour
Exclusion criteria
1. Recent (< 6 months) thoracic surgery 2. Recent (< 6 months) pneumothorax 3. Deemed unsuitable for CPAP by respiratory physician
Outcome results
None listed