None listed
Conditions
Brief summary
This trial will compare high-intensity exercise delivered in short bursts (intervals) against the typical moderate intensity exercise that is used during cardiac rehabilitation. The study will be a randomised controlled trial. Endpoints that will be examined include aerobic fitness, blood pressure and body fat percentage.
Interventions
High-intensity interval training (HIIT) HIIT consists of 6 weeks x 2 sessions/week (12 sessions), involving stationary cycling of 15-20 repetitions × 30-second intervals at 85-90% HRmax (RPE ~14-17), interspersed with 30-second active recovery. Each session will begin with a 10-minute moderate-intensity warm-up at ~65% HRmax and ended with a 5-minute active recovery cool-down. For the first 3-weeks of training, all patients will complete 15 repetitions per session (including 2 passive rests for BP measurement – after the 5th and 10th repetition); in the final 3-weeks of training, patients will complete 20 repetitions per session (including 1 passive rest – after the 10th repetition). The passive rest periods will be ~30-seconds or until BP measurement has been accurately recorded. Workloads are determined by the clinical staff (physiotherapists and exercise physiologists) to maintain the target HR (and/or RPE) range for the 5- or 10-repetition block (before a passive rest for BP measurement). HR and RPE will be recorded in the last 5 seconds of every 5th work interval. HR and BP will be monitored during the cool-down period to ensure patient safety. The total time commitment for each HIIT session is 30 minutes (for 15 total repetitions) to 35 minutes (for 20 total repetitions), equating to mean across all sessions 32.5 minutes.
Sponsors
Study design
Eligibility
Inclusion criteria
1. Age between 18 and 75 years 2. Documented coronary artery disease (CAD), specifically recent acute myocardial infarction (MI), percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG), or, treated valvular heart disease, specifically following valve repair or replacement 3. Clinically stable for at least 4 weeks following AMI or PCI, or 6 weeks following CABG or other surgery requiring sternotomy 4. NYHA Class I 5. Sinus rhythm 6. First-time participant at the CR 7. Left ventricular ejection fraction > 40% 8. Receiving optimal medical treatment 9. Successful completion of a 2 session ‘run-in’ period of exercise training at the CR (‘usual care’ consisting of low to moderate-intensity continuous aerobic exercise and light-intensity resistance exercises). 10. Treating cardiologist’s clear approval for participation 11. Negative exercise stress test result
Exclusion criteria
Primary diagnosis of heart failure; having a pacemaker; haemodynamically significant valvular disease; severe chronic obstructive pulmonary disease; unstable symptomatology; post-surgical tachycardia; cognitive impairment; not fluent in English; unable to undertake cycling exercise; women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study; or other co-morbidities precluding participation in a structured exercise programme.