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High-intensity interval training within cardiac rehabilitation: a multi-center randomized controlled trial.

Comparison of high-intensity interval training and moderate-intensity continuous training in patients with coronary artery disease on completion rates within cardiac rehabilitation service.

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12619001737123
Enrollment
64
Registered
2019-12-09
Start date
2020-02-03
Completion date
2022-10-03
Last updated
2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This trial will compare high-intensity exercise delivered in short bursts (intervals) against the typical moderate intensity exercise that is used during cardiac rehabilitation. The study will be a randomised controlled trial. Endpoints that will be examined include aerobic fitness, blood pressure and body fat percentage.

Interventions

High-intensity interval training (HIIT) HIIT consists of 6 weeks x 2 sessions/week (12 sessions), involving stationary cycling of 15-20 repetitions × 30-second intervals at 85-90% HRmax (RPE ~14-17), interspersed with 30-second active recovery. Each session will begin with a 10-minute moderate-intensity warm-up at ~65% HRmax and ended with a 5-minute active recovery cool-down. For the first 3-weeks of training, all patients will complete 15 repetitions per session (including 2 passive rests for

High-intensity interval training (HIIT) HIIT consists of 6 weeks x 2 sessions/week (12 sessions), involving stationary cycling of 15-20 repetitions × 30-second intervals at 85-90% HRmax (RPE ~14-17), interspersed with 30-second active recovery. Each session will begin with a 10-minute moderate-intensity warm-up at ~65% HRmax and ended with a 5-minute active recovery cool-down. For the first 3-weeks of training, all patients will complete 15 repetitions per session (including 2 passive rests for BP measurement – after the 5th and 10th repetition); in the final 3-weeks of training, patients will complete 20 repetitions per session (including 1 passive rest – after the 10th repetition). The passive rest periods will be ~30-seconds or until BP measurement has been accurately recorded. Workloads are determined by the clinical staff (physiotherapists and exercise physiologists) to maintain the target HR (and/or RPE) range for the 5- or 10-repetition block (before a passive rest for BP measurement). HR and RPE will be recorded in the last 5 seconds of every 5th work interval. HR and BP will be monitored during the cool-down period to ensure patient safety. The total time commitment for each HIIT session is 30 minutes (for 15 total repetitions) to 35 minutes (for 20 total repetitions), equating to mean across all sessions 32.5 minutes.

Sponsors

Prince of Wales Hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator)

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

1. Age between 18 and 75 years 2. Documented coronary artery disease (CAD), specifically recent acute myocardial infarction (MI), percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG), or, treated valvular heart disease, specifically following valve repair or replacement 3. Clinically stable for at least 4 weeks following AMI or PCI, or 6 weeks following CABG or other surgery requiring sternotomy 4. NYHA Class I 5. Sinus rhythm 6. First-time participant at the CR 7. Left ventricular ejection fraction > 40% 8. Receiving optimal medical treatment 9. Successful completion of a 2 session ‘run-in’ period of exercise training at the CR (‘usual care’ consisting of low to moderate-intensity continuous aerobic exercise and light-intensity resistance exercises). 10. Treating cardiologist’s clear approval for participation 11. Negative exercise stress test result

Exclusion criteria

Primary diagnosis of heart failure; having a pacemaker; haemodynamically significant valvular disease; severe chronic obstructive pulmonary disease; unstable symptomatology; post-surgical tachycardia; cognitive impairment; not fluent in English; unable to undertake cycling exercise; women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study; or other co-morbidities precluding participation in a structured exercise programme.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026