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Influence of altitude on cerebral and splanchnic oxygen saturation in critically ill children during air ambulance transport

Influence of altitude on cerebral and splanchnic oxygen saturation in critically ill children during air ambulance transport

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12619001710112
Enrollment
39
Registered
2019-12-04
Start date
2014-01-14
Completion date
2019-01-21
Last updated
2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Near-infrared spectroscopy (NIRS) measures regional oxygen saturation (rSO2) of the underlying tissue. During air transport the effects of altitude on patient oxygenation are of special importance. With increasing altitude, barometric pressure decreases and as a result also the partial pressure of oxygen. The result is lower oxygen saturations. The primary aim of the current study is to investigate how cerebral and splanchnic oxygen saturation in critically ill children transported in air ambulance was affected by flight with cabin pressurization corresponding to 5000 feet or higher.

Interventions

A cerebral and a splanchnic Near-infrared (NIRS) sensor were used to register regional oxygen saturation (rSO2) during transport of critically ill children in air ambulance. Participants were monitored for the entire flight with flights ranging from 60 minutes to 6 hours. The electronically stored data from the INVOS 5100C from 39 patients were afterwards extracted and examined to investigate how cerebral and splanchnic oxygen saturation was affected by flight with cabin pressurization correspon

A cerebral and a splanchnic Near-infrared (NIRS) sensor were used to register regional oxygen saturation (rSO2) during transport of critically ill children in air ambulance. Participants were monitored for the entire flight with flights ranging from 60 minutes to 6 hours. The electronically stored data from the INVOS 5100C from 39 patients were afterwards extracted and examined to investigate how cerebral and splanchnic oxygen saturation was affected by flight with cabin pressurization corresponding to altitudes at 5000 feet or higher.

Sponsors

Karolinska University Hospital
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
No minimum to 15 Years
Healthy volunteers
No

Inclusion criteria

Children scheduled for inter-hospital transport by a specialized pediatric transport team at the Pediatric Intensive Care Unit (PICU) at the Astrid Lindgren Children’s Hospital, Karolinska University Hospital in Stockholm, Sweden.

Exclusion criteria

Flights with an estimated duration less than 50 minutes and flights with a need for sea level cabin altitude. Lack of informed consent, participation in any other clinical research study,

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026