None listed
Conditions
Brief summary
In order to prolong peritoneal dialysis [PD] technique survival, clinicians not only need to focus on protecting patient’s residual kidney function and peritoneal membrane integrity, they also need to address the impact of PD on patient’s daily living. One potential solution is the use of incremental PD (5 days a week dialysis). We have designed an investigator-initiated study to answer the following questions: Is incremental PD a feasible dialysis prescription? • Can PD patients be safely maintained on incremental PD • How long does incremental PD last, until needing daily PD By having regular peritoneal membrane resting, does incremental PD • Maintain residual renal function and urine output? • Improve patient’s life participation? • Better preserve peritoneal membrane function? The study will recruit adult patients who have commenced peritoneal dialysis in the previous 3 months and has been designed to fit in with PD patients' standard of care so minimal additional pathology testing will be required. We expect the incremental dialysis group to report better quality of life and demonstrate non-inferiority in terms of safety data and peritonitis rates.
Interventions
Incremental peritoneal dialysis, by performing five days a week of dialysis instead of daily, will be compared to daily peritoneal dialysis, in incident peritoneal dialysis patients. This type of dialysis is usually performed on a daily basis, by the patients in their own homes. There is a wide range of treatment duration (from 8 to 24 hours, depending on patient preference and their dialysis requirement, and usually lasts 3-5 years). Peritoneal dialysis can either be done manually (aided by gra
Incremental peritoneal dialysis, by performing five days a week of dialysis instead of daily, will be compared to daily peritoneal dialysis, in incident peritoneal dialysis patients. This type of dialysis is usually performed on a daily basis, by the patients in their own homes. There is a wide range of treatment duration (from 8 to 24 hours, depending on patient preference and their dialysis requirement, and usually lasts 3-5 years). Peritoneal dialysis can either be done manually (aided by gravity), or using an automated machine pump - both are the standard of care and are chosen by patients depending on their lifestyle. This study is not a comparison between manual vs automated techniques; rather, it aims to compare 5 days versus daily dialysis. Adherence of incremental or daily peritoneal dialysis will be reviewed during three monthly clinic visits, telephone reviews, as well as assessing remote monitoring data built in to dialysis machines (in participating units).
Sponsors
Eastern Health
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Able to provide informed consent. Residual kidney creatinine clearance >50 L/week/1.73m^2 on 24 hour urine collection.
Exclusion criteria
Been on haemodialysis or peritoneal dialysis for >3 months. Life expectancy <1 year.
Outcome results
None listed