Cognitive impairment in patients with lymphoma

Conditions

None listed

Brief summary

The purpose of this study is to assess the feasibility of collecting data on cognition over the course of treatment and recovery in patients with newly diagnosed aggressive lymphoma Who is it for? You may be eligible for this study if you are an adult who has been newly diagnosed with aggressive lymphoma, that is undergoing treatment at Austin Health. Study details All participants in this study will complete their usual treatment as prescribed by their doctor. Participants in this study will be assessed at three timepoints over the course of their treatment and recovery – one before treatment starts, one halfway, and one at the end of the treatment period. The assessment session will involve some tests to assess cognitive function and, in those participants willing to participate, a MRI brain scan and/or a PET/CT brain scan. It is hoped that this research will help determine if a larger study looking at cognitive function during chemotherapy for lymphoma is possible, adding to an underexplored area of cancer research.

Charlotte Ditchfield, Priscilla Gates, Juan F. Domínguez D, Haryana M. Dhillon, Vincent Doré et al. (7 authors)

Frontiers in Neurology2025-09-171 citations

10.3389/fneur.2025.1601459

Gates P, Krishnasamy M, Wilson C, Hawkes EA, Doré V, Perchyonok Y, Rowe CC, Walker AK, Vardy JL, de Ruiter MB, Cushion T, Dhillon HM, Dhillon HM, Gough K.

2022-06-1410 citations

10.1007/s00520-022-07153-9

Exploration of motivation to participate in a study of cancer-related cognitive impairment among patients with newly diagnosed aggressive lymphoma: a qualitative sub-study.

Gates P, Dhillon H, Dhillon H, Gough K, Wilson C, Hawkes E, Scudder L, Cushion T, Krishnasamy M.

2021-09-085 citations

10.1007/s00520-021-06527-9

Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study

Priscilla Gates, Karla Gough, Haryana M. Dhillon, Carlene Wilson, Eliza A. Hawkes et al. (12 authors)

BMJ Open2020-09-0112 citations

10.1136/bmjopen-2020-038312

Interventions

This longitudinal, feasibility study sets out to explore the pattern of cancer related cognitive impairment in thirty patients with newly diagnosed aggressive lymphoma receiving standard therapy with curative intent, using validated questionnaires, neuropsychological testing, blood-cell inflammatory markers and neuroimaging over a period of eighteen months.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

Inclusion criteria: 1. Age greater than or equal to 18 years 2. Newly diagnosed aggressive lymphoma that requires standard chemotherapy treatment with curative intent at Austin Health. Including: • Hodgkin lymphoma • Diffuse large B cell lymphoma • Burkitt lymphoma • Transformed follicular lymphoma • Grade 3b follicular lymphoma 3. Able to read and comprehend English instructions. 4. Eastern Collaborative Oncology Group (ECOG) performance status less than or equal to 2

Exclusion criteria

Exclusion criteria: 1. Central Nervous System (CNS) lymphoma 2. Prior/planned cranial radiotherapy 3. An expected life expectancy < 12 months 4. Medical conditions that may compromise compliance or lead to prolonged hospitalisation 5. Documented history of or current substance abuse 6. Concurrent poorly controlled psychiatric illness.

Outcome results