None listed
Conditions
Brief summary
Knee Osteoarthritis affects many people, causing significant pain and immobility. At present, there are very few effective treatments available to managing pain in patients with osteoarthritis. This study is designed to investigate a new treatment, called a 'Genicular nerve block'. This study aims to demonstrate that 'Genicular nerve block' is a safe and effective method for treating knee osteoarthritis.
Interventions
Assess for reduction of pain in patients with knee OA when treated with Genicular nerve block compared to placebo. The interventional procedure will be performed by a consultant Radiologist or Rheumatologist who is experienced in administering Genicular nerve blocks under ultrasound guidance.
Intervention
Patient will be positioned supine with a pillow under the popliteal fossa for comfort
Under Ultrasound guidance the superior lateral genicular nerve, superior medial genicular nerve, and infe
Assess for reduction of pain in patients with knee OA when treated with Genicular nerve block compared to placebo. The interventional procedure will be performed by a consultant Radiologist or Rheumatologist who is experienced in administering Genicular nerve blocks under ultrasound guidance. Intervention Patient will be positioned supine with a pillow under the popliteal fossa for comfort Under Ultrasound guidance the superior lateral genicular nerve, superior medial genicular nerve, and inferior medial genicular nerve will by identified by using the corresponding artery as a guide Under sterile non touch technique with 1ml lidocaine 2% local anaesthetic each nerve will be infiltrated with 5.7mg celestone chronodose (1ml) + 3mL 0.5% bupivacaine at each target site The study will be conducted at Flinders Medical Centre The procedure is expected to take approximately 30 minutes Patients will receive a single Genicular nerve block, and then outcome measures will be recorded at a number of time intervals for 12 weeks following the procedure.
Sponsors
Rheumatology Department, Flinders Medical Centre
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adults aged 18 yo or older of either sex with knee OA referred for knee replacement surgery Participants must have knee OA as per ACR classification criteria and chronic knee pain with pain intensity of at least 4/10 on the VAS on most or all days for > 3 months
Exclusion criteria
Patients with systemic inflammatory joint disease Allergy to local anaesthetic Pregnant women Patients who have undergoing an intra-articular corticosteroid injection to the affected knee/s 3 months prior to enrolment Patients who are likely to be non-compliant with follow up Patients who will be unable to provide written informed consent
Outcome results
None listed