None listed
Conditions
Brief summary
Atrial fibrillation (AF) is common irregular rapid heart rhythm which happens in about 5% of people. Some patients have symptoms regardless of medication and a procedure is needed to get rid of these symptoms. This procedure uses an electrical current to burn the pathway between the top and the bottom part of the heart. What is not known is the way the heart changes after the procedure and if the benefits are due only to a slower heart rate or more complex processes. One way to measure the heart's response to the procedure is by taking blood to test for cardiac biomarkers (BNP and cTnI). Currently it is unknown how these biomarkers respond immediately after the procedure. Our study will enroll 30 patients who are having this procedure. Blood samples will be taken from the heart and artery during the procedure to measure BNP and cTnI. How the levels of BNP and TnI react during the procedure will help us decide the site in the heart where these are released from and what triggers their release.
Interventions
The study will measure levels of the proteins brain natriuretic peptide (BNP) and troponin (hs-TnI) in a prospective cohort of patients undergoing atrioventricular (AV) node ablation and measure the differences before and after the procedure. Blood samples will be collected from three different sites, the vein, the artery and within the heart (coronary sinus) at the start of the procedure and then 20 and 40 minutes following the procedure. The study will be conducted on the day of the procedure
The study will measure levels of the proteins brain natriuretic peptide (BNP) and troponin (hs-TnI) in a prospective cohort of patients undergoing atrioventricular (AV) node ablation and measure the differences before and after the procedure. Blood samples will be collected from three different sites, the vein, the artery and within the heart (coronary sinus) at the start of the procedure and then 20 and 40 minutes following the procedure. The study will be conducted on the day of the procedure only.
Sponsors
Princess Alexandra Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
o Age greater than or equal to 18 years o Permanent atrial fibrillation o Left ventricular ejection fraction (LVEF) >45% o Clinical indication for AV node ablation o Permanent pacemaker already implanted or planned to be implanted prior to AV node ablation o Able to provide written informed consent
Exclusion criteria
o Age < 18 years o Inability to provide consent o LVEF <45% or decompensated heart failure o Severe valvular lesions o Pregnancy
Outcome results
None listed