None listed
Conditions
Brief summary
Osteoporosis is a frequent finding in people with Coeliac Disease at the time of diagnosis; rigorous compliance with a gluten-free diet after diagnosis does not result in full recovery of bone health in a significant proportion of individuals. We hypothesise that the Gut-Bone Axis becomes dysfunctional in Coeliac Disease and that the bone tissue continues to produce signals which affect bone turnover and cause the gut to be persistently inflamed, compromising nutrient absorption and promoting hypersensitivity to dietary components. We will compare bone health (by a DXA scan of bone mineral density and Quantitative Ultrasound (QUS)) and bone metabolism (using blood-borne markers of bone turnover) and nutrient status in women with Coeliac Disease, with healthy controls and women who have Non-Coeliac Gluten Sensitivity.
Interventions
This study aims to investigate bone health in women with coeliac disease (CD) and non-coeliac gluten sensitivity (NCGS) compared with matched healthy controls. This study will require participants to complete a three-day diet diary in the week prior to their visit to the research unit, to assess nutrient intake. During their visit to the research unit they will have bone health assessed (bone mineral density, DXA; Quantitative Ultrasound, QUS); complete questionnaires to assess nutrient intake a
This study aims to investigate bone health in women with coeliac disease (CD) and non-coeliac gluten sensitivity (NCGS) compared with matched healthy controls. This study will require participants to complete a three-day diet diary in the week prior to their visit to the research unit, to assess nutrient intake. During their visit to the research unit they will have bone health assessed (bone mineral density, DXA; Quantitative Ultrasound, QUS); complete questionnaires to assess nutrient intake and physical activity level including retrospective information about past nutrient intake and exercise. In addition they will also have venous bloods to measure bone health (bone metabolism, CTX), nutrient status (vitamin B12; folate), markers of inflammatory status (CRP), thyroid function (namely TSH-h; T3 free; T4; Tg; anti-Tg; anti-TPO), calcium homeostasis (calcium; vitamin D; parathyroid hormone) and disease status (markers of coeliac disease - tissue-transglutaminase; endomysial antibodies). The overall duration will be one visit to the research unit of about 2 hours plus additional time outside of this visit to complete a three-day diet diary. No follow up is planned.
Sponsors
Massey University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
To become a participant, you will need to: - Be a healthy female consuming a normal gluten-containing diet. OR - Be a female medically diagnosed with coeliac disease (by biopsy), who has consumed a strict gluten free diet for at least 12 months OR - Be a female medically diagnosed with non-coeliac gluten sensitivity (i.e. have received a negative diagnosis for coeliac disease by serology and biopsy but have been medically advised to adhere to a GF diet due to improvements in symptoms), who has consumed a strict gluten free diet for at least 12 months AND - Be aged between 18-40 years - Live in the Palmerston North and Wellington Regions
Exclusion criteria
Previous/current medication affecting bone metabolism (e.g. corticosteroids, bisphosphonates, selective oestrogen receptor modulators); medical conditions affecting bone health; pregnancy and lactation; known history of inflammatory conditions other than CD and NCGS; BMI>30 (derived from screening questionnaire); have not had your condition medically diagnosed according to standard criteria (for the CD and NCGS group).
Outcome results
None listed