None listed
Conditions
Brief summary
The aim of this study is to investigate the safety, feasibility and efficacy of an anti-inflammatory diet prescription to dampening inflammatory pathways, in conjunction with standard medical therapy, on disease activity, and the gut microbiota composition in individuals with mild to moderate disease.
Interventions
Following the completion of screening patients will be randomized to intervention arm or control arm. In the intervention arm patients will receive IBD-MAID (IBD modified anti-inflammatory diet) meals for lunch and dinner and advised on appropriate breakfast and snack options by the dietitian at a 1 hour face to face appointment. All meals provided and breakfast/snack options/recipes will align with IBD MAID guidelines (contain no artificial sweeteners, emulsifiers, cured/processed meats and must combine to meet the daily targets of pro-inflammatory diet constituents such as extra virgin olive oil, fruits, vegetables and wholegrains daily). Participants in the control group will see the dietitian face to face for a 1 hour appointment for general dietary advice (GDA) and be provided with recipes from the eat for health national campaign for the 8 week period. Baseline measures will be repeated at week 8 and participants will have a 1 week washout period before being crossed over to the intervention arm. After the 8 week intervention period all participants will be invited to continue following the IBD MAID diet for a further 10 months. Consenting participants will receive further IBD MAID education and counselling from the dietitian at the 8 week follow up 30-45 minute face to face appointment. Participants will have the contact details of the dietitian for support during the intervention period. The dietitian will also send participants new recipes monthly during the 10 month period and participants will be contacted monthly by the dietitian via telehealth or phone (~10 mins) to provide additional dietary support and guidance. IBD MAID dietary adherence will be assessed by an online 3 day food diary completed monthly and checklist of key dietary nutrients completed weekly.
Sponsors
Study design
Eligibility
Inclusion criteria
Diagnosis of UC or CD established for at least 3 months prior to time of consent Mild to moderate disease activity at time of consent
Exclusion criteria
- Become pregnant or are currently pregnant or lactating - Current smokers or individuals who have ceased smoking within12 months prior to screening - Excessive ETOH consumption as defined as >2glasses per day - Multiple food allergies/intolerances which may affect ability to follow the diet prescription.