Changes in blood potassium levels in adult patients undergoing liver transplantation

Peak serum potassium levels during reperfusion in adult patients undergoing primary cadaveric liver transplantation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12619001488190

Enrollment

Registered

2019-10-29

Start date

2018-05-21

Completion date

2018-07-30

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this study is to identify the time point of peak serum potassium levels during the reperfusion phase of adult liver transplantation. We aim to assess the the changes in blood potassium levels from baseline values during reperfusion, and evaluate clinical factors that may be associated with the development of hyperkalaemia. Who is it for? This is a retrospective study evaluating potassium levels in adult patients undergoing primary orthotropic liver transplantation. Study details The aim of this study is to quantify the changes in potassium during the reperfusion phase of liver transplantation. Elevated recipient serum potassium levels have been identified as an independent risk factor for post-operative mortality in liver transplantation. Further, severe hyperkalemia at reperfusion can result in cardiac arrhythmias and cardiac asystole if not adequately monitored and treated. We consider the incidence and severity of hyperkalaemia in this setting. In addition, we will highlight the importance of evaluating the changes in potassium relevant to patients undergoing liver transplantation. It is hoped that this study will be hypothesis generating and provide valuable data for power calculations for future studies on evaluating changes in potassium values during reperfusion. Further, we will provide an in-depth insight of the changes in serum potassium levels during the reperfusion stage to guide clinicians caring for such patients.

Interventions

There is no participant involvement as this is a retrospective review of the patient medical records. The medical records of thirty consecutive patients undergoing primary cadaveric liver transplantation will be retrospectively evaluated. From this retrospective cohort we will use the hospital electronic medical record system (CERNER) to identify the blood potassium levels during reperfusion of the donor liver in patients undergoing primary cadaveric liver transplantation. Hyperkalaemia, defined according to international criteria, is a serum potassium above 5.5 mol/L. The duration of observation per participant is from admission to hospital to discharge from hospital. The is no collection of data for the post discharge period.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Inclusion criteria will be adult patients (>18 years of age) undergoing primary cadaveric orthotopic liver transplantation. .

Exclusion criteria

We will exclude the following patients: 1. Patients undergoing multiorgan transplant 2. Pregnancy 3. Patients with fulminant liver failure.

Outcome results